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Title: The impact of abdominal compression on outcome in patients treated with stereotactic body radiotherapy for primary lung cancer.
Authors: Mampuya, Wambaka Ange
Matsuo, Yukinori  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-4372-8259 (unconfirmed)
Ueki, Nami
Nakamura, Mitsuhiro
Mukumoto, Nobutaka
Nakamura, Akira
Iizuka, Yusuke
Kishi, Takahiro
Mizowaki, Takashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8135-8746 (unconfirmed)
Hiraoka, Masahiro
Author's alias: 松尾, 幸憲
Keywords: abdominal compression
clinical outcome
stereotactic body radiation therapy
non-small cell lung cancer
Issue Date: Sep-2014
Publisher: Oxford University Press
Journal title: Journal of radiation research
Volume: 55
Issue: 5
Start page: 934
End page: 939
Abstract: The aim of this study was to evaluate the impact of abdominal compression (AC) on outcome in patients treated with stereotactic body radiotherapy (SBRT) for primary lung cancer. We retrospectively reviewed data for 47 patients with histologically proven non-small cell lung cancer and lung tumour motion ≥ 8 mm treated with SBRT. Setup error was corrected based on bony structure. The differences in overall survival (OS), local control (LC) and disease-free survival (DFS) were evaluated to compare patients treated with AC (n = 22) and without AC (n = 25). The median follow-up was 42.6 months (range, 1.4-94.6 months). The differences in the 3-year OS, LC and DFS rate between the two groups were not statistically significant (P = 0.909, 0.209 and 0.639, respectively). However, the largest difference was observed in the LC rate, which was 82.5% (95% CI, 54.9-94.0%) for patients treated without AC and 65.4% (95% CI, 40.2-82.0%) for those treated with AC. After stratifying the patients into prognostic groups based on sex and T-stage, the LC difference increased in the group with an unfavourable prognosis. The present study suggests that AC might be associated with a worse LC rate after SBRT using a bony-structure-based set-up.
Rights: © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/191228
DOI(Published Version): 10.1093/jrr/rru028
PubMed ID: 24801474
Appears in Collections:Journal Articles

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