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Title: Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid.
Authors: Park, Jungha
Yamaura, Takayuki
Kawamoto, Jun
Kurihara, Tatsuo  kyouindb  KAKEN_id  orcid (unconfirmed)
Sato, Satoshi B
Author's alias: 佐藤, 智
Issue Date: 21-Jan-2014
Publisher: Public Library of Science
Journal title: PloS one
Volume: 9
Issue: 1
Thesis number: e85045
Abstract: Annexin A2 (ANXA2), a member of the annexin family of cytosolic Ca(2+)-binding proteins, plays a pivotal role in vascular biology. Small amounts of this protein and S100A10 protein are exposed on the surface of endothelial cells (ECs). They control fibrinolysis by recruiting tissue-type and urokinase-type plasminogen activators from the plasma. Nutritional studies indicate that two major long-chain polyunsaturated fatty acids (PUFAs), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), provide benefits for EC functions. The effects of EPA and DHA on the plasminogen/plasmin system have not been characterized.
Rights: © 2014 Park et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0085045
PubMed ID: 24465474
Appears in Collections:Journal Articles

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