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タイトル: | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. |
著者: | Park, Jungha Yamaura, Takayuki Kawamoto, Jun Kurihara, Tatsuo https://orcid.org/0000-0002-7777-1378 (unconfirmed) Sato, Satoshi B |
著者名の別形: | 佐藤, 智 |
発行日: | 21-Jan-2014 |
出版者: | Public Library of Science |
誌名: | PloS one |
巻: | 9 |
号: | 1 |
論文番号: | e85045 |
抄録: | Annexin A2 (ANXA2), a member of the annexin family of cytosolic Ca(2+)-binding proteins, plays a pivotal role in vascular biology. Small amounts of this protein and S100A10 protein are exposed on the surface of endothelial cells (ECs). They control fibrinolysis by recruiting tissue-type and urokinase-type plasminogen activators from the plasma. Nutritional studies indicate that two major long-chain polyunsaturated fatty acids (PUFAs), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), provide benefits for EC functions. The effects of EPA and DHA on the plasminogen/plasmin system have not been characterized. |
著作権等: | © 2014 Park et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/191236 |
DOI(出版社版): | 10.1371/journal.pone.0085045 |
PubMed ID: | 24465474 |
出現コレクション: | 学術雑誌掲載論文等 |
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