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j.seizure.2014.06.002.pdf282.11 kBAdobe PDF見る/開く
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dc.contributor.authorKobayashi, Katsuyaen
dc.contributor.authorHitomi, Takefumien
dc.contributor.authorMatsumoto, Rikien
dc.contributor.authorKondo, Takayukien
dc.contributor.authorKawamata, Junen
dc.contributor.authorMatsuhashi, Masaoen
dc.contributor.authorHashimoto, Shujien
dc.contributor.authorIkeda, Hitoshien
dc.contributor.authorKoide, Yasumichien
dc.contributor.authorInoue, Yushien
dc.contributor.authorTakahashi, Ryosukeen
dc.contributor.authorIkeda, Akioen
dc.contributor.alternative小林, 勝哉ja
dc.contributor.alternative池田, 昭夫ja
dc.date.accessioned2014-11-25T02:02:45Z-
dc.date.available2014-11-25T02:02:45Z-
dc.date.issued2014-10-
dc.identifier.issn1059-1311-
dc.identifier.urihttp://hdl.handle.net/2433/191240-
dc.description.abstract[Purpose]To delineate chronological changes of cortical hyperexcitability by long-term follow-up of the amplitudes of somatosensory evoked potentials (SEPs) in patients with Japanese Unverricht–Lundborg disease (ULD). [Method]SEPs to median nerve stimulation were repeatedly examined in 7 genetically diagnosed ULD patients with the mean interval of 11.9 years. The degree of temporal changes in the amplitude of 3 early cortical components, N20, P25 and N35, to the age was analyzed and compared with that of healthy subjects. [Results]Their clinical course was almost stable during the follow-up period, namely cessation of generalized tonic-clonic seizures and little or no progression of myoclonus. SEP amplitudes of P25 and N35 were enlarged in all patients and were gradually decreased with aging in ULD on average. The degree of temporal changes of P25 and N35 in ULD was similar or even lower than that of healthy subjects. [Conclusion]Enlarged but relatively stable SEP amplitudes had a consistency with so-called self-limited clinical course in Japanese ULD. SEP amplitude could be one of the surrogate markers of the degree of cortical hyperexcitability in ULD during the long-term follow-up period.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier Ltd.en
dc.rights© 2014 British Epilepsy Association. Published by Elsevier Ltd.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.rightsThis is not the published version. Please cite only the published version.en
dc.subjectUnverricht–Lundborg diseaseen
dc.subjectSomatosensory evoked potentialen
dc.subjectGiant SEPen
dc.titleLong-term follow-up of cortical hyperexcitability in Japanese Unverricht-Lundborg disease.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleSeizureen
dc.identifier.volume23-
dc.identifier.issue9-
dc.identifier.spage746-
dc.identifier.epage750-
dc.relation.doi10.1016/j.seizure.2014.06.002-
dc.textversionauthor-
dc.identifier.pmid25023721-
dcterms.accessRightsopen access-
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