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タイトル: | Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. |
著者: | Isomura, Akihiro Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) |
著者名の別形: | 磯村, 彰宏 影山, 龍一郎 |
キーワード: | Negative feedback Optogenetics Ultradian oscillator Systems biology |
発行日: | Oct-2014 |
出版者: | Company of Biologists Ltd. |
誌名: | Development |
巻: | 141 |
号: | 19 |
開始ページ: | 3627 |
終了ページ: | 3636 |
抄録: | Biological clocks play key roles in organismal development, homeostasis and function. In recent years, much work has focused on circadian clocks, but emerging studies have highlighted the existence of ultradian oscillators - those with a much shorter periodicity than 24 h. Accumulating evidence, together with recently developed optogenetic approaches, suggests that such ultradian oscillators play important roles during cell fate decisions, and analyzing the functional links between ultradian oscillation and cell fate determination will contribute to a deeper understanding of the design principle of developing embryos. In this Review, we discuss the mechanisms of ultradian oscillatory dynamics and introduce examples of ultradian oscillators in various biological contexts. We also discuss how optogenetic technology has been used to elucidate the biological significance of ultradian oscillations. |
著作権等: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
URI: | http://hdl.handle.net/2433/191242 |
DOI(出版社版): | 10.1242/dev.104497 |
PubMed ID: | 25249457 |
出現コレクション: | 学術雑誌掲載論文等 |
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