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Title: Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions.
Authors: Isomura, Akihiro  kyouindb  KAKEN_id
Kageyama, Ryoichiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 磯村, 彰宏
影山, 龍一郎
Keywords: Negative feedback
Ultradian oscillator
Systems biology
Issue Date: Oct-2014
Publisher: Company of Biologists Ltd.
Journal title: Development
Volume: 141
Issue: 19
Start page: 3627
End page: 3636
Abstract: Biological clocks play key roles in organismal development, homeostasis and function. In recent years, much work has focused on circadian clocks, but emerging studies have highlighted the existence of ultradian oscillators - those with a much shorter periodicity than 24 h. Accumulating evidence, together with recently developed optogenetic approaches, suggests that such ultradian oscillators play important roles during cell fate decisions, and analyzing the functional links between ultradian oscillation and cell fate determination will contribute to a deeper understanding of the design principle of developing embryos. In this Review, we discuss the mechanisms of ultradian oscillatory dynamics and introduce examples of ultradian oscillators in various biological contexts. We also discuss how optogenetic technology has been used to elucidate the biological significance of ultradian oscillations.
Rights: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
DOI(Published Version): 10.1242/dev.104497
PubMed ID: 25249457
Appears in Collections:Journal Articles

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