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j.chembiol.2014.07.019.pdf | 1.2 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Syed, Junetha | en |
dc.contributor.author | Pandian, Ganesh N | en |
dc.contributor.author | Sato, Shinsuke | en |
dc.contributor.author | Taniguchi, Junichi | en |
dc.contributor.author | Chandran, Anandhakumar | en |
dc.contributor.author | Hashiya, Kaori | en |
dc.contributor.author | Bando, Toshikazu | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | 杉山, 弘 | ja |
dc.date.accessioned | 2014-11-25T05:53:18Z | - |
dc.date.available | 2014-11-25T05:53:18Z | - |
dc.date.issued | 2014-10-23 | - |
dc.identifier.issn | 1074-5521 | - |
dc.identifier.uri | http://hdl.handle.net/2433/191246 | - |
dc.description.abstract | Human ectopic viral integration site 1 (EVI1) is an oncogenic transcription factor known to play a critical role in many aggressive forms of cancer. Its selective modulation is thought to alter the cancer-specific gene regulatory networks. Pyrrole-imidazole polyamides (PIPs) are a class of small DNA binders that can be designed to target any destined DNA sequence. Herein, we report a sequence-specific pyrrole-imidazole polyamide, PIP1, which can target specific base pairs of the REL/ELK1 binding site in the EVI1 minimal promoter. The designed PIP1 significantly inhibited EVI1 in MDA-MB-231 cells. Whole-transcriptome analysis confirmed that PIP1 affected a fraction of EVI1-mediated gene regulation. In vitro assays suggested that this polyamide can also effectively inhibit breast cancer cell migration. Taken together, these results suggest that EVI1-targeted PIP1 is an effective transcriptional regulator in cancer cells. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd. | en |
dc.rights | © 2014 Elsevier Ltd. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11072585 | - |
dc.identifier.jtitle | Chemistry & biology | en |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1370 | - |
dc.identifier.epage | 1380 | - |
dc.relation.doi | 10.1016/j.chembiol.2014.07.019 | - |
dc.textversion | author | - |
dc.identifier.pmid | 25219965 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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