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dc.contributor.author | Nakagawa, Takayuki | en |
dc.contributor.author | Kumakawa, Kozo | en |
dc.contributor.author | Usami, Shin-ichi | en |
dc.contributor.author | Hato, Naohito | en |
dc.contributor.author | Tabuchi, Keiji | en |
dc.contributor.author | Takahashi, Mariko | en |
dc.contributor.author | Fujiwara, Keizo | en |
dc.contributor.author | Sasaki, Akira | en |
dc.contributor.author | Komune, Shizuo | en |
dc.contributor.author | Sakamoto, Tatsunori | en |
dc.contributor.author | Hiraumi, Harukazu | en |
dc.contributor.author | Yamamoto, Norio | en |
dc.contributor.author | Tanaka, Shiro | en |
dc.contributor.author | Tada, Harue | en |
dc.contributor.author | Yamamoto, Michio | en |
dc.contributor.author | Yonezawa, Atsushi | en |
dc.contributor.author | Ito-Ihara, Toshiko | en |
dc.contributor.author | Ikeda, Takafumi | en |
dc.contributor.author | Shimizu, Akira | en |
dc.contributor.author | Tabata, Yasuhiko | en |
dc.contributor.author | Ito, Juichi | en |
dc.contributor.alternative | 中川, 隆之 | ja |
dc.date.accessioned | 2014-12-11T04:14:50Z | - |
dc.date.available | 2014-12-11T04:14:50Z | - |
dc.date.issued | 2014-11-19 | - |
dc.identifier.issn | 1741-7015 | - |
dc.identifier.uri | http://hdl.handle.net/2433/192275 | - |
dc.description | 突発性難聴に対する新規治療法の有効性を報告. 京都大学プレスリリース. 2014-12-10. | ja |
dc.description.abstract | [Background]To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to intratympanic corticosteroid therapy. [Methods]We randomly assigned patients with sudden deafness refractory to systemic corticosteroids to receive either gelatin hydrogels impregnated with IGF-1 in the middle ear (62 patients) or four intratympanic injections with dexamethasone (Dex; 58 patients). The primary outcome was the proportion of patients showing hearing improvement (10 decibels or greater in pure-tone average hearing thresholds) 8 weeks after treatment. The secondary outcomes included the change in pure-tone average hearing thresholds over time and the incidence of adverse events. [Results]In the IGF-1 group, 66.7% (95% confidence interval [CI], 52.9–78.6%) of the patients showed hearing improvement compared to 53.6% (95% CI, 39.7–67.0%) of the patients in the Dex group (P = 0.109). The difference in changes in pure-tone average hearing thresholds over time between the two treatments was statistically significant (P = 0.003). No serious adverse events were observed in either treatment group. Tympanic membrane perforation did not persist in any patient in the IGF-1 group, but did persist in 15.5% (95% CI, 7.3–27.4%) of the patients in the Dex group (P = 0.001). [Conclusions]The positive effect of topical IGF-1 application on hearing levels and its favorable safety profile suggest utility for topical IGF-1 therapy in patients with sudden deafness. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central Ltd. | en |
dc.rights | © 2014 Nakagawa et al.; licensee BioMed Central Ltd. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.subject | Dexamethasone | en |
dc.subject | Drug delivery system | en |
dc.subject | IGF-1 | en |
dc.subject | Local application | en |
dc.subject | Sudden sensorineural hearing loss | en |
dc.title | A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | BMC medicine | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.1186/s12916-014-0219-x | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 219 | - |
dc.identifier.pmid | 25406953 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2014-12-10 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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