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dc.contributor.authorMiyake, Ayumija
dc.contributor.authorChitose, Tatsuyaja
dc.contributor.authorKamei, Erikoja
dc.contributor.authorMurakami, Atsukoja
dc.contributor.authorNakayama, Yoshiakija
dc.contributor.authorKonishi, Morichikaja
dc.contributor.authorItoh, Nobuyukija
dc.contributor.alternative三宅, 歩ja
dc.description.abstractFibroblast growth factor (Fgf) signaling plays crucial roles in various developmental processes including those in the brain. We examined the role of Fgf16 in the formation of the zebrafish brain. The knockdown of fgf16 decreased cell proliferation in the forebrain and midbrain. fgf16 was also essential for development of the ventral telencephalon and diencephalon, whereas fgf16 was not required for dorsoventral patterning in the midbrain. fgf16 was additionally required for the specification and differentiation of γ-aminobutyric acid (GABA)ergic interneurons and oligodendrocytes, but not for those of glutamatergic neurons in the forebrain. Cross talk between Fgf and Hedgehog (Hh) signaling was critical for the specification of GABAergic interneurons and oligodendrocytes. The expression of fgf16 in the forebrain was down-regulated by the inhibition of Hh and Fgf19 signaling, but not by that of Fgf3/Fgf8 signaling. The fgf16 morphant phenotype was similar to that of the fgf19 morphant and embryos blocked Hh signaling. The results of the present study indicate that Fgf16 signaling, which is regulated by the downstream pathways of Hh-Fgf19 in the forebrain, is involved in forebrain development.ja
dc.publisherPublic Library of Scienceja
dc.rights© 2014 Miyake et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ja
dc.titleFgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain.ja
dc.type.niitypeJournal Articleja
dc.identifier.jtitlePloS oneja
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