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タイトル: | The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates |
著者: | Morimoto, Daichi https://orcid.org/0000-0002-7672-2136 (unconfirmed) Walinda, Erik https://orcid.org/0000-0003-1882-6401 (unconfirmed) Fukada, Harumi Sou, Yu-Shin Kageyama, Shun Hoshino, Masaru https://orcid.org/0000-0003-4099-0232 (unconfirmed) Fujii, Takashi Tsuchiya, Hikaru Saeki, Yasushi Arita, Kyohei Ariyoshi, Mariko Tochio, Hidehito https://orcid.org/0000-0003-3843-3330 (unconfirmed) Iwai, Kazuhiro https://orcid.org/0000-0001-5620-5951 (unconfirmed) Namba, Keiichi Komatsu, Masaaki Tanaka, Keiji Shirakawa, Masahiro |
著者名の別形: | 森本, 大智 白川, 昌宏 |
キーワード: | Biological sciences Biochemistry Cell biology |
発行日: | 20-Jan-2015 |
出版者: | Nature Publishing Group |
誌名: | Nature Communications |
巻: | 6 |
論文番号: | 6116 |
抄録: | Ubiquitin is known to be one of the most soluble and stably folded intracellular proteins, but it is often found in inclusion bodies associated with various diseases including neurodegenerative disorders and cancer. To gain insight into this contradictory behaviour, we have examined the physicochemical properties of ubiquitin and its polymeric chains that lead to aggregate formation. We find that the folding stability of ubiquitin chains unexpectedly decreases with increasing chain length, resulting in the formation of amyloid-like fibrils. Furthermore, when expressed in cells, polyubiquitin chains covalently linked to EGFP also form aggregates depending on chain length. Notably, these aggregates are selectively degraded by autophagy. We propose a novel model in which the physical and chemical instability of polyubiquitin chains drives the formation of fibrils, which then serve as an initiation signal for autophagy. |
記述: | ポリユビキチン鎖のアミロイド様線維形成を発見 -神経変性疾患における脳内異常タンパク質凝集の形成機構解明に期待-. 京都大学プレスリリース. 2015-01-21. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/193230 |
DOI(出版社版): | 10.1038/ncomms7116 |
PubMed ID: | 25600778 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2015-01-21 |
出現コレクション: | 学術雑誌掲載論文等 |
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