ダウンロード数: 1737
タイトル: | TIP (Paclitaxel, Ifosfamide, Cisplatin) 療法が著効した鼠径リンパ節転移を有する陰茎癌の1例 |
その他のタイトル: | Dramatic Response of Penile Cancer with Inguinal Lymph Node Metastases to Neoadjuvant Chemotherapy with Paclitaxel, Ifosfamide and Cisplatin : A Case Report |
著者: | 久保田, 恵章 仲野, 正博 永井, 真吾 松岡, 加恵 荒川, 裕貴 堀江, 憲吾 出口, 隆 加藤, 久和 |
著者名の別形: | Kubota, Yasuaki Nakano, Masahiro Nagai, Shingo Matsuoka, Kae Arakawa, Hirotaka Horie, Kengo Deguchi, Takashi Kato, Hisakazu |
キーワード: | Penile cancer Paclitaxel Ifosfamide, Cisplatin |
発行日: | Jan-2015 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 61 |
号: | 1 |
開始ページ: | 33 |
終了ページ: | 37 |
抄録: | Carcinoma of the penis is rare, and the prognosis of penile cancer with inguinal metastases is extremely poor. Standard chemotherapy for advanced penile cancer has not been established because of its rarity. A case of penile cancer with inguinal metastases that responded well to neoadjuvant chemotherapy with paclitaxel, ifosfamide and cisplatin (TIP) is described. A 55-year-old Japanese male visited our hospital for a penile tumor and fixed, 4 cm, right inguinal lymph nodes. Computed tomography and 18F-FDG-PET imaging showed not only right but also left inguinal lymphadenopathy. Penile cancer (clinical stage T3N3M0, 7th edition TNM classification) was diagnosed, and partial penectomy and right inguinal biopsy were performed. The pathological examination revealed squamous cell carcinoma of the penis with right inguinal lymph node metastasis. The inguinal metastases were judged to be unsuitable for radical resection ; and, paclitaxel 60 mg/m2 (day 1), ifosfamide 1, 200 mg/m2 (days 1-3), and cisplatin 60 mg/m2 (days 1-3) were given at 3-week intervals as neoadjuvant chemotherapy. After 4 courses of chemotherapy, the inguinal metastases were markedly reduced. He had neutropenia (grade 3) during each course and peripheral neuropathy after 2 courses, but there were no severe complications. The patient underwent bilateral inguinal and pelvic lymphadenectomy after neoadjuvant chemotherapy. Pathological examination revealed no viable cells in the resected specimens. The patient remains alive and well with no evidence of recurrence 8 months after this radical treatment. TIP chemotherapy appears to be effective for advanced penile cancer. |
著作権等: | 許諾条件により本文は2016/02/01に公開 |
URI: | http://hdl.handle.net/2433/193609 |
PubMed ID: | 25656018 |
出現コレクション: | Vol. 61 No. 1 |
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