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タイトル: | 抗コリン薬抵抗性の神経因性膀胱に対するミラベグロンの併用効果 : ビデオウロダイナミクスを用いた検討 |
その他のタイトル: | Efficacy of Combination Therapy with Mirabegron for Anticholinergic-Resistant Neurogenic Bladder : Videourodynamic Evaluation |
著者: | 和田, 直樹 岡崎, 智 小林, 進 橋爪, 和純 北, 雅史 松本, 成史 柿崎, 秀宏 |
著者名の別形: | Wada, Naoki Okazaki, Satoshi Kobayashi, Shin Hashizume, Kazumi Kita, Masafumi Matsumoto, Seiji Kakizaki, Hidehiro |
キーワード: | Neurogenic bladder Mirabegron |
発行日: | Jan-2015 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 61 |
号: | 1 |
開始ページ: | 7 |
終了ページ: | 11 |
抄録: | Using a videourodynamic study, we examined the efficacy of combination therapy with mirabegron for anticholinergic-resistant neurogenic bladder. We retrospectively studied 7 patients with neurogenic bladder (5 males and 2 females) who had detrusor overactivity (DO) or low compliance bladder (<10 ml/cmH2O) despite taking anticholinergic medication. Bladder deformity was categorized from G0 to G3 by Ogawa’s classification. Mean age of study patients was 51 years (25-76). Underlying diseases were spinal cord injury in 3 patients, spina bifida in 2, spinal cord infarction in 1, and post-radical hysterectomy in 1. Preceding anticholinergic medication was solifenacin 5 mg in 1 patient, solifenacin 10 mg in 5, and tolterodine 4 mg in 1. Before mirabegron, bladder deformity was G1 in 4 patients, G2 in 1 and G3 in 2, and vesicoureteral reflux (VUR) was detected in 3 patients. Five and 4 patients had detrusor overactivity and low compliance bladder, respectively. Videourodynamic study was reevaluated at a mean of 7 months (2- 12 months) after mirabegron. After mirabegron, urinary incontinence was improved in all patients. G3 bladder deformity was improved to G2 and G1 in one patient each, and VUR disappeared in all 3 patients. DO disappeared in 2 of the 5 patients, and bladder compliance was improved in all 4 patients with low compliance bladder. In conclusion, combination therapy of mirabegron is effective and beneficial for anticholinergic-resistant neurogenic bladder. |
著作権等: | 許諾条件により本文は2016/02/01に公開 |
URI: | http://hdl.handle.net/2433/193614 |
PubMed ID: | 25656013 |
出現コレクション: | Vol. 61 No. 1 |
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