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タイトル: | The structural basis for receptor recognition of human interleukin-18. |
著者: | Tsutsumi, Naotaka Kimura, Takeshi Arita, Kyohei Ariyoshi, Mariko Ohnishi, Hidenori Yamamoto, Takahiro Zuo, Xiaobing Maenaka, Katsumi Park, Enoch Y Kondo, Naomi Shirakawa, Masahiro Tochio, Hidehito https://orcid.org/0000-0003-3843-3330 (unconfirmed) Kato, Zenichiro |
著者名の別形: | 堤, 尚孝 白川, 昌宏 杤尾, 豪人 |
キーワード: | Biological sciences Biochemistry Immunology |
発行日: | 15-Dec-2014 |
出版者: | Nature Publishing Group |
誌名: | Nature communications |
巻: | 5 |
論文番号: | 5340 |
抄録: | Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors' recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-18 activity. |
記述: | 免疫・神経難治疾患の治療薬開発を促進するインターロイキン18複合体立体構造を解明. 京都大学プレスリリース. 2014-12-16. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/194151 |
DOI(出版社版): | 10.1038/ncomms6340 |
PubMed ID: | 25500532 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2014-12-16 |
出現コレクション: | 学術雑誌掲載論文等 |
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