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dc.contributor.authorFunahashi, Shintaroen
dc.contributor.alternative船橋, 新太郎ja
dc.date.accessioned2015-03-10T00:56:52Z-
dc.date.available2015-03-10T00:56:52Z-
dc.date.issued2015-02-05-
dc.identifier.issn1662-5137-
dc.identifier.urihttp://hdl.handle.net/2433/196035-
dc.description.abstractWorking memory (WM) is one of key concepts to understand functions of the prefrontal cortex. Delay-period activity is an important neural correlate to understand the role of WM in prefrontal functions. The importance of delay-period activity is that this activity can encode not only visuospatial information but also a variety of information including non-spatial visual features, auditory and tactile stimuli, task rules, expected reward, and numerical quantity. This activity also participates in a variety of information processing including sensory-to-motor information transformation. These mnemonic features of delay-period activity enable to perform various important operations that the prefrontal cortex participates in, such as executive controls, and therefore, support the notion that WM is an important function to understand prefrontal functions. On the other hand, although experiments using manual versions of the delayed-response task had revealed many important findings, an oculomotor version of this task enabled us to use multiple cue positions, exclude postural orientation during the delay period, and further prove the importance of mnemonic functions of the prefrontal cortex. In addition, monkeys with unilateral lesions exhibited specific impairment only in the performance of memory-guided saccades directed toward visual cues in the visual field contralateral to the lesioned hemisphere. This result indicates that memories for visuospatial coordinates in each hemifield are processed primarily in the contralateral prefrontal cortex. This result further strengthened the idea of mnemonic functions of the prefrontal cortex. Thus, the mnemonic functions of the prefrontal cortex and delay-period activity may not need to be reconsidered, but should be emphasized.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherFrontiersen
dc.rights© 2015 Funahashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectprefrontal cortexen
dc.subjectworking memoryen
dc.subjectmnemonic scotomaen
dc.subjectdelay-period activityen
dc.subjectdelayed-response tasken
dc.subjectspatial-information processingen
dc.titleFunctions of delay-period activity in the prefrontal cortex and mnemonic scotomas revisited.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleFrontiers in systems neuroscienceen
dc.identifier.volume9-
dc.relation.doi10.3389/fnsys.2015.00002-
dc.textversionpublisher-
dc.identifier.artnum2-
dc.identifier.pmid25698942-
dcterms.accessRightsopen access-
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