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Title: Morphological study of the accommodative apparatus in the monkey eye.
Authors: Hiraoka, Mari
Inoue, Kenichi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5683-5280 (unconfirmed)
Senoo, Haruki
Takada, Masahiko  kyouindb  KAKEN_id
Author's alias: 平岡, 満里
Keywords: accommodation
zonule
fibrillin
elastin
fibronectin
collagen
Issue Date: Mar-2015
Publisher: Wiley Periodicals, Inc.
Journal title: Anatomical record
Volume: 298
Issue: 3
Start page: 630
End page: 636
Abstract: For more than a century there has been debate concerning the mechanism of accommodation-whether the lens capsule or lens material itself determines the functional relationship between ciliary muscle contractility and lens deformation during refractive adaptation. This morphological study in monkey eyes investigates the composition and distribution of several connective tissue components in the accommodative apparatus relaying muscle force to lens organization. Elastin distributes on the marginal surface of the ciliary process. A zonule is composed of fibrillin produced by epithelial cells of the process. In the progress of extension over the posterior chamber, fibrils unite into strands and possess longitudinal plasticity. By induction of the elastin network, strands extend in a concentric direction covering the equatorial region of the capsule. Upon tethering to the lens, the strand ramifies into fibrils, penetrating deeply close to the epithelial layer of the lens and binding with the collagen of the intercellular spaces. Tight linkage of the zonule with the capsule transmits precise contractility. Inside the lens, the cortical layer's elastic connective tissue network forms widely spaced lamellae of crystalline fibers. In contrast, the central nuclear lamellae are tightly opposed. The accumulation of lamellae is greater in the anterior cortex than in the posterior, yielding a more variable anterior chamber depth in the visual axis. The plasticity of the zonule and connective tissue distribution inside the lens produces an adjustable configuration. Thus, tight linkage between the dynamism of the capsule with interaction of the lenticular flexibility provides a novel understanding of accommodation.
Rights: © The Authors The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/196080
DOI(Published Version): 10.1002/ar.23100
PubMed ID: 25403484
Appears in Collections:Journal Articles

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