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dc.contributor.author | Aoyama, Tomoki | en |
dc.contributor.author | Fujita, Yasuko | en |
dc.contributor.author | Madoba, Katsuyuki | en |
dc.contributor.author | Nankaku, Manabu | en |
dc.contributor.author | Yamada, Minoru | en |
dc.contributor.author | Tomita, Motoko | en |
dc.contributor.author | Goto, Koji | en |
dc.contributor.author | Ikeguchi, Ryosuke | en |
dc.contributor.author | Kakinoki, Ryosuke | en |
dc.contributor.author | Matsuda, Shuichi | en |
dc.contributor.author | Nakamura, Takashi | en |
dc.contributor.author | Toguchida, Junya | en |
dc.contributor.alternative | 青山, 朋樹 | ja |
dc.contributor.alternative | 後藤, 公志 | ja |
dc.contributor.alternative | 池口, 良輔 | ja |
dc.contributor.alternative | 松田, 秀一 | ja |
dc.contributor.alternative | 戸口田, 淳也 | ja |
dc.date.accessioned | 2015-03-31T07:27:15Z | - |
dc.date.available | 2015-03-31T07:27:15Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0003-9993 | - |
dc.identifier.uri | http://hdl.handle.net/2433/196637 | - |
dc.description.abstract | [Objective]To determine the feasibility and safety of implementing a 12-week rehabilitation program after mesenchymal stromal cell (MSC) transplantation augmented by vascularized bone grafting for idiopathic osteonecrosis (ION) of the femoral head. [Design]A prospective case series. [Setting]University clinical research laboratory. [Participants]Participants (N=10) with ION who received MSC transplantation augmented by vascularized bone grafting. [Intervention]A 12-week exercise program, which included range-of-motion (ROM) exercises, muscle-strengthening exercises, and aerobic training. [Main Outcome Measures]Measures of ROM, muscle strength, Timed Up and Go test, and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were collected before surgery and again at 6 and 12 months after surgery. [Results]All participants completed the 12-week program. External rotation ROM as well as extensor and abductor muscle strength significantly improved 6 months after treatment compared with that before treatment (P<.05). Significant improvements were also seen in physical function, role physical, and bodily pain subgroup scores of the SF-36 (P<.05). No serious adverse events occurred. [Conclusions]This study demonstrates the feasibility and safety of a multiplex rehabilitation program after MSC transplantation and provides support for further study on the benefits of rehabilitation programs in regenerative medicine. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | This is an open access article. | en |
dc.rights | © 2015 American Congress of Rehabilitation Medicine. | en |
dc.subject | Mesenchymal stromal cells | en |
dc.subject | Osteonecrosis | en |
dc.subject | Rehabilitation | en |
dc.title | Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00548606 | - |
dc.identifier.jtitle | Archives of physical medicine and rehabilitation | en |
dc.identifier.volume | 96 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 532 | - |
dc.identifier.epage | 539 | - |
dc.relation.doi | 10.1016/j.apmr.2014.09.040 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 25450129 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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