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DCフィールド | 値 | 言語 |
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dc.contributor.author | Yamashita, Kouhei | en |
dc.contributor.author | Miyoshi, Takashi | en |
dc.contributor.author | Arai, Yasuyuki | en |
dc.contributor.author | Mizugishi, Kiyomi | en |
dc.contributor.author | Takaori-Kondo, Akifumi | en |
dc.contributor.author | Ueyama, Takehiko | en |
dc.contributor.alternative | 山下, 浩平 | ja |
dc.date.accessioned | 2015-04-02T07:14:05Z | - |
dc.date.available | 2015-04-02T07:14:05Z | - |
dc.date.issued | 2013-03-24 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | http://hdl.handle.net/2433/196751 | - |
dc.description.abstract | Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of chronic granulomatous disease (CGD), a rare inherited disorder of phagocytes that is characterized by a defect in the production of reactive oxygen species (ROS) caused by mutations in NADPH oxidase 2. Here, we report a case of successful treatment of IPA complicated with CGD by the administration of interferon-γ (IFN-γ) in combination with voriconazole. The patient carried a splice site mutation in the CYBB gene, and the neutrophils could produce a certain amount of ROS. In this case, augmentation of ROS generation in the patient's neutrophils was observed after in vivo IFN-γ treatment, which may be attributable to the induction of a normal CYBB gene in the myeloid progenitor cells. This treatment, in combination with voriconazole, may have contributed to the reversal of IPA in this patient. These results suggest that the in vivo use of IFN-γ may augment ROS generation in CGD neutrophils, thus leading to the successful treatment of severe IPA. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Japan | en |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s12185-013-1315-y | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Chronic granulomatous disease | en |
dc.subject | Invasive pulmonary aspergillosis | en |
dc.subject | Interferon-γ | en |
dc.subject | Reactive oxygen species | en |
dc.subject | Voriconazole | en |
dc.subject.mesh | Adult | en |
dc.subject.mesh | Antifungal Agents/administration & dosage | en |
dc.subject.mesh | Antifungal Agents/therapeutic use | en |
dc.subject.mesh | Cell Line | en |
dc.subject.mesh | Exons | en |
dc.subject.mesh | Gene Order | en |
dc.subject.mesh | Granulomatous Disease, Chronic/complications | en |
dc.subject.mesh | Granulomatous Disease, Chronic/diagnosis | en |
dc.subject.mesh | Granulomatous Disease, Chronic/genetics | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Interferon-gamma/biosynthesis | en |
dc.subject.mesh | Interferon-gamma/pharmacology | en |
dc.subject.mesh | Interferon-gamma/therapeutic use | en |
dc.subject.mesh | Invasive Pulmonary Aspergillosis/diagnosis | en |
dc.subject.mesh | Invasive Pulmonary Aspergillosis/drug therapy | en |
dc.subject.mesh | Invasive Pulmonary Aspergillosis/etiology | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Membrane Glycoproteins/genetics | en |
dc.subject.mesh | Mutation | en |
dc.subject.mesh | NADPH Oxidase/genetics | en |
dc.subject.mesh | Neutrophils/drug effects | en |
dc.subject.mesh | Neutrophils/metabolism | en |
dc.subject.mesh | Reactive Oxygen Species/metabolism | en |
dc.subject.mesh | Tomography Scanners, X-Ray Computed | en |
dc.title | Enhanced generation of reactive oxygen species by interferon-γ may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10797094 | - |
dc.identifier.jtitle | International journal of hematology | en |
dc.identifier.volume | 97 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 505 | - |
dc.identifier.epage | 510 | - |
dc.relation.doi | 10.1007/s12185-013-1315-y | - |
dc.textversion | author | - |
dc.identifier.pmid | 23526099 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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