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s12282-012-0363-0.pdf | 1.14 MB | Adobe PDF | 見る/開く |
タイトル: | Photoacoustic mammography: initial clinical results. |
著者: | Kitai, Toshiyuki Torii, Masae Sugie, Tomoharu Kanao, Shotaro Mikami, Yoshiki Shiina, Tsuyoshi Toi, Masakazu https://orcid.org/0000-0003-1488-9958 (unconfirmed) |
著者名の別形: | 鍛, 利幸 |
キーワード: | Photoacoustic mammography Optical imaging Near-infrared Breast cancer Tumor vascularity Oxygenation |
発行日: | 7-Apr-2012 |
出版者: | Springer Japan |
誌名: | Breast cancer |
巻: | 21 |
号: | 2 |
開始ページ: | 146 |
終了ページ: | 153 |
抄録: | [Purpose]Photoacoustic tomography can image the hemoglobin distribution and oxygenation state inside tissue with high spatial resolution. The purpose of this study is to investigate its clinical usefulness for diagnosis of breast cancer and evaluation of therapeutic response in relation to other diagnostic modalities. [Materials and methods]Using a prototype machine for photoacoustic mammography (PAM), 27 breast tumor lesions, including 21 invasive breast cancer (IBC), five ductal carcinoma in situ (DCIS), and one phyllodes tumor, were measured. Nine out of twenty-one IBC patients had received primary systemic therapy (PST). [Results]Eight out of twelve IBC without PST were visible. Notably, detection was possible in all five cases with DCIS, whereas it was not in one case with phyllodes tumor. Seven out of nine IBC with PST were assigned as visible in spite of decreased size of tumor after PST. The mean value of hemoglobin saturation in the visible lesions was 78.6 %, and hemoglobin concentration was 207 μM. The tumor images of PAM were comparable to those of magnetic resonance imaging (MRI). [Conclusions]It is suggested that PAM can image tumor vascularity and oxygenation, which may be useful for diagnosis and characterization of breast cancer. |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s12282-012-0363-0 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/196854 |
DOI(出版社版): | 10.1007/s12282-012-0363-0 |
PubMed ID: | 22484692 |
出現コレクション: | 学術雑誌掲載論文等 |
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