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Title: Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.
Authors: Terao, Chikashi  kyouindb  KAKEN_id
Asai, Keita  kyouindb  KAKEN_id
Hashimoto, Motomu  kyouindb  KAKEN_id
Yamazaki, Toru
Ohmura, Koichiro
Yamaguchi, Akihiko  kyouindb  KAKEN_id
Takahashi, Katsu  kyouindb  KAKEN_id
Takei, Noriko
Ishii, Takanori
Kawaguchi, Takahisa
Tabara, Yasuharu  kyouindb  KAKEN_id
Takahashi, Meiko  kyouindb  KAKEN_id
Nakayama, Takeo  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7918-6252 (unconfirmed)
Kosugi, Shinji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-6036-6491 (unconfirmed)
Sekine, Akihiro
Fujii, Takao
Yamada, Ryo  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1587-630X (unconfirmed)
Mimori, Tsuneyo
Matsuda, Fumihiko
Bessho, Kazuhisa  kyouindb  KAKEN_id
Author's alias: 寺尾, 知可史
橋本, 求
別所, 和久
Keywords: Epidemiological study
Periodontal disease
ACPA
RF
Association study
Rheumatoid arthritis
Issue Date: 26-Mar-2015
Publisher: Elsevier Ltd.
Journal title: Journal of autoimmunity
Volume: 59
Start page: 85
End page: 90
Abstract: Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production.
Description: 歯周病と関節リウマチ発症との相関を示す. 京都大学プレスリリース. 2015-04-21.
Rights: © 2015 Elsevier Ltd. NOTICE: this is the author's version of a work that was accepted for publication in Journal of Autoimmunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Autoimmunity, vol.59 pp.85-90 (2015), doi:10.1016/j.jaut.2015.03.002
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/197526
DOI(Published Version): 10.1016/j.jaut.2015.03.002
PubMed ID: 25819755
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2015-04-21
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