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Title: | Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study. |
Authors: | Terao, Chikashi ![]() ![]() Asai, Keita ![]() ![]() Hashimoto, Motomu ![]() ![]() Yamazaki, Toru Ohmura, Koichiro Yamaguchi, Akihiko ![]() ![]() Takahashi, Katsu ![]() ![]() Takei, Noriko Ishii, Takanori Kawaguchi, Takahisa Tabara, Yasuharu ![]() ![]() Takahashi, Meiko ![]() ![]() Nakayama, Takeo ![]() ![]() ![]() Kosugi, Shinji ![]() ![]() ![]() Sekine, Akihiro Fujii, Takao Yamada, Ryo ![]() ![]() ![]() Mimori, Tsuneyo Matsuda, Fumihiko Bessho, Kazuhisa ![]() ![]() |
Author's alias: | 寺尾, 知可史 橋本, 求 別所, 和久 |
Keywords: | Epidemiological study Periodontal disease ACPA RF Association study Rheumatoid arthritis |
Issue Date: | 26-Mar-2015 |
Publisher: | Elsevier Ltd. |
Journal title: | Journal of autoimmunity |
Volume: | 59 |
Start page: | 85 |
End page: | 90 |
Abstract: | Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production. |
Description: | 歯周病と関節リウマチ発症との相関を示す. 京都大学プレスリリース. 2015-04-21. |
Rights: | © 2015 Elsevier Ltd. NOTICE: this is the author's version of a work that was accepted for publication in Journal of Autoimmunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Autoimmunity, vol.59 pp.85-90 (2015), doi:10.1016/j.jaut.2015.03.002 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/197526 |
DOI(Published Version): | 10.1016/j.jaut.2015.03.002 |
PubMed ID: | 25819755 |
Related Link: | https://www.kyoto-u.ac.jp/ja/research-news/2015-04-21 |
Appears in Collections: | Journal Articles |

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