|Title:||Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.|
|Authors:||Terao, Chikashi |
Nakayama, Takeo https://orcid.org/0000-0002-7918-6252 (unconfirmed)
Kosugi, Shinji https://orcid.org/0000-0001-6036-6491 (unconfirmed)
Yamada, Ryo https://orcid.org/0000-0002-1587-630X (unconfirmed)
|Author's alias:||寺尾, 知可史|
|Journal title:||Journal of autoimmunity|
|Abstract:||Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production.|
|Description:||歯周病と関節リウマチ発症との相関を示す. 京都大学プレスリリース. 2015-04-21.|
|Rights:||© 2015 Elsevier Ltd. NOTICE: this is the author's version of a work that was accepted for publication in Journal of Autoimmunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Autoimmunity, vol.59 pp.85-90 (2015), doi:10.1016/j.jaut.2015.03.002|
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|Appears in Collections:||Journal Articles |
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