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Title: Estimation of proliferative potentiality of central neurocytoma: correlational analysis of minimum ADC and maximum SUV with MIB-1 labeling index.
Authors: Sakamoto, Ryo
Okada, Tomohisa  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2312-5677 (unconfirmed)
Kanagaki, Mitsunori
Yamamoto, Akira  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8894-3622 (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Kakigi, Takahide
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4626-4645 (unconfirmed)
Takahashi, Jun C
Mikami, Yoshiki
Togashi, Kaori
Author's alias: 坂本, 亮
岡田, 知久
Keywords: Central neurocytoma
central nervous system (CNS)
brain
MR diffusion
positron emission tomography (PET)
Issue Date: 29-Jan-2014
Publisher: SAGE Publications
Journal title: Acta radiologica
Volume: 56
Issue: 1
Start page: 114
End page: 120
Abstract: Background Central neurocytoma was initially believed to be benign tumor type, although atypical cases with more aggressive behavior have been reported. Preoperative estimation for proliferating activity of central neurocytoma is one of the most important considerations for determining tumor management. Purpose To investigate predictive values of image characteristics and quantitative measurements of minimum apparent diffusion coefficient (ADCmin) and maximum standardized uptake value (SUVmax) for proliferative activity of central neurocytoma measured by MIB-1 labeling index (LI). Material and Methods Twelve cases of central neurocytoma including one recurrence from January 2001 to December 2011 were included. Preoperative scans were conducted in 11, nine, and five patients for computed tomography (CT), diffusion-weighted imaging (DWI), and fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET), respectively, and ADCmin and SUVmax of the tumors were measured. Image characteristics were investigated using CT, T2-weighted (T2W) imaging and contrast-enhanced T1-weighted (T1W) imaging, and their differences were examined using the Fisher's exact test between cases with MIB-1 LI below and above 2%, which is recognized as typical and atypical central neurocytoma, respectively. Correlational analysis was conducted for ADCmin and SUVmax with MIB-1 LI. A Pvalue <0.05 was considered significant. Results Morphological appearances had large variety, and there was no significant correlation with MIB-1 LI except a tendency that strong enhancement was observed in central neurocytomas with higher MIB-1 LI (P = 0.061). High linearity with MIB-1 LI was observed in ADCmin and SUVmax (r = −0.91 and 0.74, respectively), but only ADCmin was statistically significant (P = 0.0006). Conclusion Central neurocytoma had a wide variety of image appearance, and assessment of proliferative potential was considered difficult only by morphological aspects. ADCmin was recognized as a potential marker for differentiation of atypical central neurocytomas from the typical ones.
Rights: © 2014 by The Foundation Acta Radiologica
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/198568
DOI(Published Version): 10.1177/0284185114521187
PubMed ID: 24477268
Appears in Collections:Journal Articles

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