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dc.contributor.author | Shibuya, Erika | en |
dc.contributor.author | Murakami, Masaru | en |
dc.contributor.author | Kondo, Makoto | en |
dc.contributor.author | Kamei, Yasutomi | en |
dc.contributor.author | Tomonaga, Shozo | en |
dc.contributor.author | Matsui, Tohru | en |
dc.contributor.author | Funaba, Masayuki | en |
dc.contributor.alternative | 舟場, 正幸 | ja |
dc.date.accessioned | 2015-07-10T07:27:10Z | - |
dc.date.available | 2015-07-10T07:27:10Z | - |
dc.date.issued | 2013-09-20 | - |
dc.identifier.issn | 0263-6484 | - |
dc.identifier.uri | http://hdl.handle.net/2433/198734 | - |
dc.description.abstract | Previous studies indicate that muscle Pgc-1α expression governs the proportion of muscle fibre types. As a first step in using diet to manipulate the proportion of muscle fibre types by using Pgc-1α expression, the present study investigates the modulation of Pgc-1α expression by feedstuffs. A luciferase-based Pgc-1α reporter construct (Pgc-1α(-2553)-luc) that contains the mouse Pgc-1α promoter (-2553 to +78 bp) was prepared. A screen of ethanol extracts from 33 feedstuffs indicated that oolong tea and roasted green tea extracts decreased Pgc-1α(-2553)-luc expression in C2C12 myoblasts. The transcriptional repression of Pgc-1α by tea leaf extracts was reproduced in hepatic HepG2 cells. We further examined the effects of the alcohol extracts of tea waste and its silage on Pgc-1α transcription; the tea waste silage extract inhibited Pgc-1α transcription. Treatment with the extracts of raw tea leaves, tea waste and tea waste silage effectively decreased Pgc-1α mRNA levels during myogenesis of myosatellite cells. The present results suggest that tea leaves and their by-products could be used to modulate proportions of muscle fibre types. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | wiley | en |
dc.rights | This is the peer reviewed version of the following article: Shibuya, E., Murakami, M., Kondo, M., Kamei, Y., Tomonaga, S., Matsui, T. and Funaba, M. (2014), Downregulation of Pgc-1α expression by tea leaves and their by-products. Cell Biochem. Funct., 32: 236–240, which has been published in final form at http://dx.doi.org/10.1002/cbf.3006. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Pgc-1α | en |
dc.subject | skeletal muscle | en |
dc.subject | tea leaf | en |
dc.subject | muscle fibre type | en |
dc.subject | feedstuffs | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Camellia sinensis/chemistry | en |
dc.subject.mesh | Cells, Cultured | en |
dc.subject.mesh | Down-Regulation | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Plant Extracts/pharmacology | en |
dc.subject.mesh | Plant Leaves/chemistry | en |
dc.subject.mesh | Promoter Regions, Genetic | en |
dc.subject.mesh | Rats | en |
dc.subject.mesh | Rats, Wistar | en |
dc.subject.mesh | Satellite Cells, Skeletal Muscle/drug effects | en |
dc.subject.mesh | Satellite Cells, Skeletal Muscle/metabolism | en |
dc.subject.mesh | Tea | en |
dc.subject.mesh | Transcription Factors/genetics | en |
dc.subject.mesh | Transcription Factors/metabolism | en |
dc.subject.mesh | Transcription, Genetic | en |
dc.title | Downregulation of Pgc-1α expression by tea leaves and their by-products. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell biochemistry and function | en |
dc.identifier.volume | 32 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 236 | - |
dc.identifier.epage | 240 | - |
dc.relation.doi | 10.1002/cbf.3006 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2014-09-20 | - |
dc.identifier.pmid | 24114933 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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