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Title: A dual-task paradigm for behavioral and neurobiological studies in nonhuman primates.
Authors: Watanabe, Kei
Funahashi, Shintaro
Author's alias: 船橋, 新太郎
Keywords: Monkey
Behavioral neurophysiology
Dual-task paradigm
Training protocol
Issue Date: 10-Mar-2015
Publisher: Elsevier B.V.
Journal title: Journal of neuroscience methods
Volume: 246
Start page: 1
End page: 12
Abstract: [Background]The dual-task paradigm is a procedure in which subjects are asked to perform two behavioral tasks concurrently, each of which involves a distinct goal with a unique stimulus–response association. Due to the heavy demand on subject's cognitive abilities, human studies using this paradigm have provided detailed insights regarding how the components of cognitive systems are functionally organized and implemented. Althoughdual-task paradigms are widely used in human studies, they are seldom used in nonhuman animal studies. [New method]We propose a novel dual-task paradigm for monkeys that requires the simultaneous performance of two cognitively demanding component tasks, each of which uses an independent effector for behavioral responses (hand and eyes). We provide a detailed description of an optimal training protocol for this paradigm, which has been lacking in the existing literature. [Results]An analysis of behavioral performance showed that the proposed dual-task paradigm (1) was quickly learned by monkeys (less than 40 sessions) with step-by-step training protocols, (2) produced specific behavioral effects, known as dual-task interference in human studies, and (3) achieved rigid and independent control of the effectors for behavioral responses throughout the trial. [Comparison with existing methods]The proposed dual-task paradigm has a scalable task structure, in that each of the two component tasks can be easily replaced by other tasks, while preserving the overall structure of the paradigm. [Conclusions]This paradigm should be useful for investigating executive control that underlies dual-task performance at both the behavioral and neuronal levels.
Rights: © 2015 Elsevier B.V. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. NOTICE: this is the author's version of a work that was accepted for publication in Journal of Neuroscience Methods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroscience Methods, Volume 246, Pages 1–12, doi:10.1016/j.jneumeth.2015.03.006.
許諾条件により本文ファイルは2016-09-10に公開.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/198807
DOI(Published Version): 10.1016/j.jneumeth.2015.03.006
PubMed ID: 25769271
Appears in Collections:Journal Articles

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