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dc.contributor.author | Hirota, Keisho | en |
dc.contributor.author | Yasoda, Akihiro | en |
dc.contributor.author | Fujii, Toshihito | en |
dc.contributor.author | Inagaki, Nobuya | en |
dc.contributor.alternative | 八十田, 明宏 | ja |
dc.date.accessioned | 2015-08-19T02:42:02Z | - |
dc.date.available | 2015-08-19T02:42:02Z | - |
dc.date.issued | 2014-03-05 | - |
dc.identifier.issn | 1757-790X | - |
dc.identifier.uri | http://hdl.handle.net/2433/199586 | - |
dc.description.abstract | A 52-year-old woman with overlap syndrome and interstitial pneumonia underwent immunosuppressive therapy and she was suspected to suffer from pulmonary aspergillosis. Oral voriconazole was initiated, and a rapid elevation of alkaline phosphatase (ALP) occurred after 4 weeks. After 2 months, the patient presented diffuse pain in bilateral skeletal regions, and bone scintigraphy revealed bilateral multiple areas of increased radiotracer uptake. We suspected the skeletal involvement as voriconazole-induced periostitis. Actually, the plasma fluoride level was increased. Voriconazole was replaced with itraconazole, and after 3 weeks, the patient stopped complaining of bone pain concomitant with the decrease in ALP. Voriconazole-induced periostitis is a rare condition but had previously been reported in solid organ or patients with bone marrow transplant who received a long-term voriconazole therapy. Our present case is distinctive of previous ones, because it occurred in a patient with connective tissue disease which had its rapid progression. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | en |
dc.rights | This article has been accepted for publication in BMJ Case Reports following peer review. The definitive copyedited, typeset version [Keisho Hirota, Akihiro Yasoda, Toshihito Fujii, Nobuya Inagaki. Voriconazole-induced periostitis in a patient with overlap syndromes. BMJ Case Reports 2014; doi:10.1136/bcr-2013-203485] is available online at: http://casereports.bmj.com/content/2014/bcr-2013-203485. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Antifungal Agents/adverse effects | en |
dc.subject.mesh | Antifungal Agents/therapeutic use | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Immunocompromised Host | en |
dc.subject.mesh | Immunosuppressive Agents/adverse effects | en |
dc.subject.mesh | Immunosuppressive Agents/therapeutic use | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Periostitis/chemically induced | en |
dc.subject.mesh | Periostitis/diagnosis | en |
dc.subject.mesh | Pulmonary Aspergillosis/drug therapy | en |
dc.subject.mesh | Pulmonary Aspergillosis/immunology | en |
dc.subject.mesh | Rheumatic Diseases/complications | en |
dc.subject.mesh | Rheumatic Diseases/drug therapy | en |
dc.subject.mesh | Voriconazole/adverse effects | en |
dc.subject.mesh | Voriconazole/therapeutic use | en |
dc.title | Voriconazole-induced periostitis in a patient with overlap syndromes. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | BMJ case reports | en |
dc.identifier.volume | 2014 | - |
dc.relation.doi | 10.1136/bcr-2013-203485 | - |
dc.textversion | author | - |
dc.identifier.pmid | 24599432 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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