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DCフィールド | 値 | 言語 |
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dc.contributor.author | Tartey, Sarang | en |
dc.contributor.author | Matsushita, Kazufumi | en |
dc.contributor.author | Vandenbon, Alexis | en |
dc.contributor.author | Ori, Daisuke | en |
dc.contributor.author | Imamura, Tomoko | en |
dc.contributor.author | Mino, Takashi | en |
dc.contributor.author | Standley, Daron M | en |
dc.contributor.author | Hoffmann, Jules A | en |
dc.contributor.author | Reichhart, Jean-Marc | en |
dc.contributor.author | Akira, Shizuo | en |
dc.contributor.author | Takeuchi, Osamu | en |
dc.contributor.alternative | 竹内, 理 | ja |
dc.date.accessioned | 2015-08-28T03:10:00Z | - |
dc.date.available | 2015-08-28T03:10:00Z | - |
dc.date.issued | 2014-10-16 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/2433/199669 | - |
dc.description.abstract | Transcription of inflammatory genes in innate immune cells is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. However, it remains unclear how microbial sensing initiates chromatin remodeling. Here, we show that Akirin2, an evolutionarily conserved nuclear protein, bridges NF-κB and the chromatin remodeling SWI/SNF complex by interacting with BRG1-Associated Factor 60 (BAF60) proteins as well as IκB-ζ, which forms a complex with the NF-κB p50 subunit. These interactions are essential for Toll-like receptor-, RIG-I-, and Listeria-mediated expression of proinflammatory genes including Il6 and Il12b in macrophages. Consistently, effective clearance of Listeria infection required Akirin2. Furthermore, Akirin2 and IκB-ζ recruitment to the Il6 promoter depend upon the presence of IκB-ζ and Akirin2, respectively, for regulation of chromatin remodeling. BAF60 proteins were also essential for the induction of Il6 in response to LPS stimulation. Collectively, the IκB-ζ-Akirin2-BAF60 complex physically links the NF-κB and SWI/SNF complexes in innate immune cell activation. By recruiting SWI/SNF chromatin remodellers to IκB-ζ, transcriptional coactivator for NF-κB, the conserved nuclear protein Akirin2 stimulates pro-inflammatory gene promoters in mouse macrophages during innate immune responses to viral or bacterial infection. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | EMBO press | en |
dc.rights | © 2014 The Authors. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Adaptor Proteins, Signal Transducing/genetics | en |
dc.subject.mesh | Adaptor Proteins, Signal Transducing/metabolism | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Cell Nucleus/metabolism | en |
dc.subject.mesh | Chromatin Assembly and Disassembly | en |
dc.subject.mesh | Chromosomal Proteins, Non-Histone/genetics | en |
dc.subject.mesh | Chromosomal Proteins, Non-Histone/metabolism | en |
dc.subject.mesh | Cytokines/metabolism | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Gene Expression Regulation | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Immunity, Innate | en |
dc.subject.mesh | Listeria monocytogenes/physiology | en |
dc.subject.mesh | Macrophages/immunology | en |
dc.subject.mesh | Macrophages/metabolism | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Knockout | en |
dc.subject.mesh | Multiprotein Complexes/genetics | en |
dc.subject.mesh | Multiprotein Complexes/metabolism | en |
dc.subject.mesh | Nuclear Proteins/genetics | en |
dc.subject.mesh | Nuclear Proteins/metabolism | en |
dc.subject.mesh | Promoter Regions, Genetic/genetics | en |
dc.subject.mesh | Protein Binding | en |
dc.subject.mesh | Repressor Proteins/genetics | en |
dc.subject.mesh | Repressor Proteins/metabolism | en |
dc.subject.mesh | Sequence Deletion | en |
dc.subject.mesh | Transcriptional Activation | en |
dc.title | Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10627582 | - |
dc.identifier.jtitle | The EMBO Journal | en |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 2332 | - |
dc.identifier.epage | 2348 | - |
dc.relation.doi | 10.15252/embj.201488447 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-04-16 | - |
dc.identifier.pmid | 25107474 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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