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タイトル: | Effect of an artificial silk elastin-like protein on the migration and collagen production of mouse fibroblasts. |
著者: | Ozaki, Chisa Somamoto, Satoshi Kawabata, Shingo Tabata, Yasuhiko |
著者名の別形: | 田畑, 泰彦 |
キーワード: | artificial silk elastin-like protein wound healing cell migration |
発行日: | 18-Jun-2014 |
出版者: | Taylor & Francis Group |
誌名: | Journal of biomaterials science. Polymer edition |
巻: | 25 |
号: | 12 |
開始ページ: | 1266 |
終了ページ: | 1277 |
抄録: | A silk elastin-like protein (SELP) is an artificial compound composing silk fibroin-like and elastin-like tandem repeats. The objective of this study is to evaluate the SELP effect on the migration, proliferation, and proteins production of L929 mouse fibroblasts. Upon culturing with different concentrations of SELP, the cells migration and their collagen production significantly enhanced in the SELP concentrations from 10(-3) to 10 μg/ml. However, irrespective of the SELP concentration, no difference in the production of fibronectin, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1α (SDF-1α) was observed. When the migration of mouse peritoneal macrophages by SELP was evaluated, significant enhancement of macrophages migration was observed in any concentration. It is concluded that the SELP has a potential to promote the migration of fibroblasts and macrophages, and the fibroblast collagen production. |
著作権等: | This is an Accepted Manuscript of an article published by Taylor & Francis in 'Journal of Biomaterials Science, Polymer Edition on [date of publication', available online: http://www.tandfonline.com/10.1080/09205063.2014.926580. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/200626 |
DOI(出版社版): | 10.1080/09205063.2014.926580 |
PubMed ID: | 24941248 |
出現コレクション: | 学術雑誌掲載論文等 |
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