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j.surg.2015.02.002.pdf | 950.1 kB | Adobe PDF | 見る/開く |
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dc.contributor.author | Okumura, Shinya | en |
dc.contributor.author | Kaido, Toshimi | en |
dc.contributor.author | Hamaguchi, Yuhei | en |
dc.contributor.author | Fujimoto, Yasuhiro | en |
dc.contributor.author | Masui, Toshihiko | en |
dc.contributor.author | Mizumoto, Masaki | en |
dc.contributor.author | Hammad, Ahmed | en |
dc.contributor.author | Mori, Akira | en |
dc.contributor.author | Takaori, Kyoichi | en |
dc.contributor.author | Uemoto, Shinji | en |
dc.contributor.alternative | 海道, 利実 | ja |
dc.date.accessioned | 2015-11-09T06:50:17Z | - |
dc.date.available | 2015-11-09T06:50:17Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0039-6060 | - |
dc.identifier.uri | http://hdl.handle.net/2433/201494 | - |
dc.description.abstract | [Background]Skeletal muscle depletion, referred to as sarcopenia, is predictive of mortality in patients undergoing digestive operations. The impact of muscle quality on outcomes, however, is unclear. This retrospective study investigated the impact of preoperative skeletal muscle quantity and quality on survival in patients undergoing resection of pancreatic cancer. [Methods]We investigated 230 patients who underwent resection of pancreatic cancer between 2004 and 2013. The quantity and quality of skeletal muscle, indicated by psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), were measured in preoperative computed tomography images. Overall survival (OS) and recurrence-free survival (RFS) rates were compared according to PMI and IMAC, and prognostic factors after pancreatic resection were assessed.[Results]The OS and RFS rates in patients with low PMI were lesser than in those with normal/high PMI (P < .001, P < .001), with a mean survival time of 17.7 and 33.2 months, respectively. The OS and RFS rates in patients with high IMAC also were less than in those with normal/low IMAC (P < .001, P = .003) (mean survival time = 21.5 and 56.5 months, respectively). Low PMI (low muscle mass) and high IMAC (low muscle quality) were independent prognostic factors of poor OS (hazard ratio [HR] = 1.999, P < .001; HR = 2.527, P < .001) and RFS (HR = 1.607, P = .007; HR = 1.640, P = .004), respectively. [Conclusion]Preoperative sarcopenia, indicating low quality and quantity of skeletal muscle, is closely related to mortality after resection of pancreatic cancer. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights | The full-text file will be made open to the public on 30 June 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Abdominal Muscles/physiopathology | en |
dc.subject.mesh | Abdominal Muscles/radiography | en |
dc.subject.mesh | Adult | en |
dc.subject.mesh | Aged | en |
dc.subject.mesh | Aged, 80 and over | en |
dc.subject.mesh | Analysis of Variance | en |
dc.subject.mesh | Cohort Studies | en |
dc.subject.mesh | Disease-Free Survival | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Follow-Up Studies | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Japan | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Neoplasm Recurrence, Local/mortality | en |
dc.subject.mesh | Neoplasm Recurrence, Local/pathology | en |
dc.subject.mesh | Organ Size/physiology | en |
dc.subject.mesh | Pancreatectomy/methods | en |
dc.subject.mesh | Pancreatectomy/mortality | en |
dc.subject.mesh | Pancreatic Neoplasms/mortality | en |
dc.subject.mesh | Pancreatic Neoplasms/pathology | en |
dc.subject.mesh | Pancreatic Neoplasms/surgery | en |
dc.subject.mesh | Predictive Value of Tests | en |
dc.subject.mesh | Preoperative Care/methods | en |
dc.subject.mesh | Retrospective Studies | en |
dc.subject.mesh | Risk Assessment | en |
dc.subject.mesh | Sarcopenia/diagnosis | en |
dc.subject.mesh | Sarcopenia/epidemiology | en |
dc.subject.mesh | Survival Analysis | en |
dc.subject.mesh | Tomography, X-Ray Computed/methods | en |
dc.subject.mesh | Treatment Outcome | en |
dc.title | Impact of preoperative quality as well as quantity of skeletal muscle on survival after resection of pancreatic cancer. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00853880 | - |
dc.identifier.jtitle | Surgery | en |
dc.identifier.volume | 157 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1088 | - |
dc.identifier.epage | 1098 | - |
dc.relation.doi | 10.1016/j.surg.2015.02.002 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2016-06-30 | - |
dc.identifier.pmid | 25799468 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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