膀胱癌舌・皮膚・脳転移に対しGT療法（Gemcitabine・Paclitaxel）が奏効した1例

Abstract

Tongue, skin and brain metastases of bladder cancer are very rare and few cases have been reported. We report a case of tongue, skin and brain metastases of bladder cancer. A 61-year-old woman was referredto our hospital with gross hematuria. Transurethral resection of the bladder (TURBT), tongue biopsy andskin biopsy were performed. Pathological findings showed urothelial carcinoma, G2, micropapillaryvariant, pT2＞ and tongue and skin metastases from urothelial carcinoma of bladder. After three cycles ofchemotherapy (gemcitabine plus paclitaxel), tongue and skin metastases disappeared. Cystoscopy revealedno tumor of bladder. Eleven months later, she was admitted to our hospital because of disturbance ofconsciousness. Magnetic resonance imaging (MRI) showed multiple brain metastases. Rechallenge ofchemotherapy (gemcitabine plus paclitaxel) restored from disturbance of consciousness and MRI showedpartial response of brain metastases. We performed six additional courses of chemotherapy. Skin, tongueand brain metastases from bladder cancer indicate poor risk. Chemotherapy (gemcitabine plus paclitaxel)could be effective against these matastases.