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タイトル: | Manipulating megakaryocytes to manufacture platelets ex vivo. |
著者: | Karagiannis, P Eto, K |
著者名の別形: | 江藤, 浩之 |
キーワード: | bioreactors blood platelets induced pluripotent stem cells megakaryocytes polyploidy |
発行日: | 19-Jun-2015 |
出版者: | wiley |
誌名: | Journal of thrombosis and haemostasis |
巻: | 13 |
号: | Special |
開始ページ: | S47 |
終了ページ: | S53 |
抄録: | Historically, platelet transfusion has proven a reliable way to treat patients suffering from thrombocytopenia or similar ailments. An undersupply of donors, however, has demanded alternative platelet sources. Scientists have therefore sought to recapitulate the biological events that convert hematopoietic stem cells into platelets in the laboratory. Such platelets have shown good function and potential for treatment. Yet the number manufactured ex vivo falls well short of clinical application. Part of the reason is the remarkable gaps in our understanding of the molecular mechanisms driving platelet formation. Using several stem cell sources, scientists have progressively clarified the chemical signaling and physical microenvironment that optimize ex vivo platelets and reconstituted them in synthetic environments. Key advances in cell reprogramming and the ability to propagate self-renewal have extended the lifetime of megakaryocytes to increase the pool of platelet progenitors. |
著作権等: | © 2015 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/201851 |
DOI(出版社版): | 10.1111/jth.12946 |
PubMed ID: | 26149050 |
出現コレクション: | 学術雑誌掲載論文等 |
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