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タイトル: | Evolutionary analyses of caspase-8 and its paralogs: Deep origins of the apoptotic signaling pathways. |
著者: | Sakamaki, Kazuhiro ![]() ![]() Imai, Kenichiro Tomii, Kentaro Miller, David J |
著者名の別形: | 酒巻, 和弘 |
キーワード: | apoptosis bcl-2 caspase coral evolution extrinsic signaling pathway sponge |
発行日: | 22-May-2015 |
出版者: | wiley |
誌名: | BioEssays |
巻: | 37 |
号: | 7 |
開始ページ: | 767 |
終了ページ: | 776 |
抄録: | Although Caenorhabditis and Drosophila proved invaluable in unraveling the molecular mechanisms of apoptosis, it is now clear that these animals are of limited value for understanding the evolution of apoptotic systems. Whereas data from these invertebrates led to the assumption that the extrinsic apoptotic pathway is restricted to vertebrates, recent data from cnidarians and sponges indicate that this pathway predates bilaterian origins. Here we review the phylogenetic distribution of caspase-8, the initiator caspase of the extrinsic apoptotic pathway, its paralogs and other components of the network. The ancestral caspase-8 gave rise to four paralogs early in vertebrate evolution, and these have been maintained in many tetrapods. However, eutherians have lost caspase-18 and myomorph rodents have lost caspase-10, these losses suggesting functional redundancy amongst caspase-8 paralogs. The apoptotic network of the eumetazoan ancestor appears to have been complex and vertebrate like, and is only now being revealed by studying simple animals. |
著作権等: | This is the peer reviewed version of the following article: Sakamaki, K., Imai, K., Tomii, K. and Miller, D. J. (2015), Evolutionary analyses of caspase-8 and its paralogs: Deep origins of the apoptotic signaling pathways. Bioessays, 37: 767–776, which has been published in final form at http://dx.doi.org/10.1002/bies.201500010. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 22 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/201883 |
DOI(出版社版): | 10.1002/bies.201500010 |
PubMed ID: | 26010168 |
出現コレクション: | 学術雑誌掲載論文等 |
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