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| j.bmcl.2015.04.072.pdf | 529.77 kB | Adobe PDF | 見る/開く |
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| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Yamada, Hisatsugu | en |
| dc.contributor.author | Hasegawa, Yoshinori | en |
| dc.contributor.author | Suzuki, Yuki | en |
| dc.contributor.author | Imai, Hirohiko | en |
| dc.contributor.author | Matsuda, Tetsuya | en |
| dc.contributor.author | Kimura, Yu | en |
| dc.contributor.author | Toshimitsu, Akio | en |
| dc.contributor.author | Aoyama, Yasuhiro | en |
| dc.contributor.author | Kondo, Teruyuki | en |
| dc.contributor.alternative | 近藤, 輝幸 | ja |
| dc.date.accessioned | 2015-11-26T02:38:35Z | - |
| dc.date.available | 2015-11-26T02:38:35Z | - |
| dc.date.issued | 2015-07-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | http://hdl.handle.net/2433/201953 | - |
| dc.description.abstract | A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier Ltd. | en |
| dc.rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
| dc.rights | The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
| dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
| dc.rights | This is not the published version. Please cite only the published version. | en |
| dc.subject | Tumor imaging | en |
| dc.subject | MRI | en |
| dc.subject | Self-traceable polymer | en |
| dc.subject | Anti-Her2 antibody | en |
| dc.subject | Active targeting | en |
| dc.title | Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment. | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.ncid | AA1079577X | - |
| dc.identifier.jtitle | Bioorganic & medicinal chemistry letters | en |
| dc.identifier.volume | 25 | - |
| dc.identifier.issue | 13 | - |
| dc.identifier.spage | 2675 | - |
| dc.identifier.epage | 2678 | - |
| dc.relation.doi | 10.1016/j.bmcl.2015.04.072 | - |
| dc.textversion | author | - |
| dc.startdate.bitstreamsavailable | 2017-07-01 | - |
| dc.identifier.pmid | 25958246 | - |
| dcterms.accessRights | open access | - |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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