ダウンロード数: 261
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
jjco_hyv039.pdf | 369.02 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Kataoka, Yuki | en |
dc.contributor.author | Yamamoto, Yosuke | en |
dc.contributor.author | Otsuki, Taiichiro | en |
dc.contributor.author | Shinomiya, Mariko | en |
dc.contributor.author | Terada, Takayuki | en |
dc.contributor.author | Fukuma, Shingo | en |
dc.contributor.author | Yamazaki, Shin | en |
dc.contributor.author | Hirabayashi, Masataka | en |
dc.contributor.author | Nakano, Takashi | en |
dc.contributor.author | Fukuhara, Shunichi | en |
dc.contributor.alternative | 福原, 俊一 | ja |
dc.date.accessioned | 2015-11-30T02:09:28Z | - |
dc.date.available | 2015-11-30T02:09:28Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1465-3621 | - |
dc.identifier.uri | http://hdl.handle.net/2433/202002 | - |
dc.description | First published online: April 2, 2015 | en |
dc.description.abstract | [Objective] Existing prognostic indices for malignant pleural mesothelioma do not incorporate the recent advances in oncology care. The purpose of this study was to provide a prognostic index for overall survival in malignant pleural mesothelioma patients treated with chemotherapy with pemetrexed or best supportive care in the recent clinical setting. [Methods] A retrospective cohort study was performed in two hospitals in Japan (2007–13). The primary outcome was overall survival. The Cox proportional hazards model was used for multivariable analyses to identify prognostic factors. A final model was chosen based on both clinical and statistical significance. [Results] A total of 283 patients (chemotherapy: n = 228, best supportive care: n = 55) were enrolled in the study. On multivariate analysis, regimen including platinum plus pemetrexed, a performance status >0, non-epithelial histological type and Stage IV disease predicted poor overall survival in chemotherapy patients. As hazard ratios of individual risk factors were approximately similar, a prognostic index for overall survival was constructed by counting the risk factors. Median overall survival in chemotherapy patients decreased by each one-point increase in this count: 1030 days for zero; 658 days for one; 373 days for two; 327 days for three; 125 days for four. Internal validation using the bootstrapping technique showed robustness of the model (c-index, 0.677; 95% confidence interval, 0.624–0.729). Further, the discrimination was consistent in best supportive care patients (c-index, 0.799; 95% confidence interval, 0.725–0.874). [Conclusions] This novel index can provide clinicians and malignant pleural mesothelioma patients with a better framework for discussing prognosis at the time of diagnosis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | en |
dc.rights | This is a pre-copyedited, author-produced PDF of an article accepted for publication in 'Japanese journal of clinical oncology' following peer review. The version of record [Yuki Kataoka, Yosuke Yamamoto, Taiichiro Otsuki, Mariko Shinomiya, Takayuki Terada, Shingo Fukuma, Shin Yamazaki, Masataka Hirabayashi, Takashi Nakano, Shunichi Fukuhara. A new prognostic index for overall survival in malignant pleural mesothelioma: the rPHS (regimen, PS, histology or stage) index. Japanese Journal of Clinical Oncology (2015) 45 (6): 562-568. doi: 10.1093/jjco/hyv039] is available online at: http://jjco.oxfordjournals.org/content/45/6/562. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | malignant pleural mesothelioma | en |
dc.subject | pemetrexed | en |
dc.subject | best supportive care | en |
dc.subject | prognostic index | en |
dc.subject | palliative care | en |
dc.subject.mesh | Adult | en |
dc.subject.mesh | Aged | en |
dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Japan/epidemiology | en |
dc.subject.mesh | Kaplan-Meier Estimate | en |
dc.subject.mesh | Lung Neoplasms/drug therapy | en |
dc.subject.mesh | Lung Neoplasms/mortality | en |
dc.subject.mesh | Lung Neoplasms/pathology | en |
dc.subject.mesh | Lung Neoplasms/therapy | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Mesothelioma/drug therapy | en |
dc.subject.mesh | Mesothelioma/mortality | en |
dc.subject.mesh | Mesothelioma/pathology | en |
dc.subject.mesh | Mesothelioma/therapy | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Neoplasm Staging | en |
dc.subject.mesh | Palliative Care/methods | en |
dc.subject.mesh | Pleural Neoplasms/drug therapy | en |
dc.subject.mesh | Pleural Neoplasms/mortality | en |
dc.subject.mesh | Pleural Neoplasms/pathology | en |
dc.subject.mesh | Pleural Neoplasms/therapy | en |
dc.subject.mesh | Predictive Value of Tests | en |
dc.subject.mesh | Prognosis | en |
dc.subject.mesh | Proportional Hazards Models | en |
dc.subject.mesh | Retrospective Studies | en |
dc.subject.mesh | Sensitivity and Specificity | en |
dc.title | A new prognostic index for overall survival in malignant pleural mesothelioma: the rPHS (regimen, PS, histology or stage) index. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Japanese journal of clinical oncology | en |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 562 | - |
dc.identifier.epage | 568 | - |
dc.relation.doi | 10.1093/jjco/hyv039 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-10-02 | - |
dc.identifier.pmid | 25838292 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。