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dc.contributor.author | Lee, Young-A | en |
dc.contributor.author | Goto, Yukiori | en |
dc.contributor.alternative | 後藤, 幸織 | ja |
dc.date.accessioned | 2015-12-01T07:47:42Z | - |
dc.date.available | 2015-12-01T07:47:42Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1673-7067 | - |
dc.identifier.uri | http://hdl.handle.net/2433/202035 | - |
dc.description | First online: 23 January 2015 | en |
dc.description.abstract | In this article, we propose the hypothesis that the prefrontal cortex (PFC) acquired neotenic development as a consequence of mesocortical dopamine (DA) innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences | en |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s12264-014-1499-z. | en |
dc.rights | The full-text file will be made open to the public on 23 January 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. | ja |
dc.subject | neurodevelopment | en |
dc.subject | neoteny | en |
dc.subject | psychiatric disorder | en |
dc.subject | stress | en |
dc.subject | animal model | en |
dc.subject | synaptic plasticity | en |
dc.subject | environmental adaptation | en |
dc.title | Prefrontal cortical dopamine from an evolutionary perspective. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Neuroscience bulletin | en |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 164 | - |
dc.identifier.epage | 174 | - |
dc.relation.doi | 10.1007/s12264-014-1499-z | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2016-01-23 | - |
dc.identifier.pmid | 25617024 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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