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dc.contributor.authorUeda, Masashien
dc.contributor.authorHisada, Hayatoen
dc.contributor.authorTemma, Takashien
dc.contributor.authorShimizu, Yoichien
dc.contributor.authorKimura, Hiroyukien
dc.contributor.authorOno, Masahiroen
dc.contributor.authorNakamoto, Yujien
dc.contributor.authorTogashi, Kaorien
dc.contributor.authorSaji, Hideoen
dc.contributor.alternative上田, 真史ja
dc.contributor.alternative佐治, 英郎ja
dc.date.accessioned2015-12-08T06:03:07Z-
dc.date.available2015-12-08T06:03:07Z-
dc.date.issued2015-02-
dc.identifier.issn1536-1632-
dc.identifier.urihttp://hdl.handle.net/2433/202106-
dc.descriptionFirst online: 22 July 2014en
dc.description.abstract【Purpose】We aimed to develop a gallium-68 (Ga-68)-labeled single-chain variable fragment (scFv) targeting the human epidermal growth factor receptor 2 (HER2) to rapidly and noninvasively evaluate the status of HER2 expression. 【Procedures】Anti-HER2 scFv was labeled with Ga-68 by using deferoxamine (Df) as a bifunctional chelate. Biodistribution of [(68)Ga]Df-anti-HER2 scFv was examined with tumor-bearing mice and positron emission tomography (PET) imaging was performed. The changes in HER2 expression after anti-HER2 therapy were monitored by PET imaging. 【Results】[(68)Ga]Df-anti-HER2 scFv was obtained with high radiochemical yield after only a 5-min reaction at room temperature. The probe showed high accumulation in HER2-positive xenografts and the intratumoral distribution of radioactivity coincided with HER2-positive regions. Furthermore, [(68)Ga]Df-anti-HER2 scFv helped visualize HER2-positive xenografts and monitor the changes in HER2 expression after anti-HER2 therapy.【Conclusion】[(68)Ga]Df-anti-HER2 scFv could be a promising probe to evaluate HER2 status by in vivoPET imaging, unless trastuzumab is prescribed as part of the therapy.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringeren
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s11307-014-0769-5.en
dc.rightsThe full-text file will be made open to the public on 22 July 2015 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.rightsThis is not the published version. Please cite only the published version.en
dc.subject.meshAnimalsen
dc.subject.meshCell Line, Tumoren
dc.subject.meshChelating Agents/chemistryen
dc.subject.meshDeferoxamine/chemistryen
dc.subject.meshFemaleen
dc.subject.meshGallium/chemistryen
dc.subject.meshGallium Radioisotopes/chemistryen
dc.subject.meshHumansen
dc.subject.meshImmunohistochemistryen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshNeoplasm Transplantationen
dc.subject.meshPositron-Emission Tomographyen
dc.subject.meshRadiopharmaceuticals/chemistryen
dc.subject.meshReceptor, ErbB-2/metabolismen
dc.subject.meshSingle-Chain Antibodies/chemistryen
dc.subject.meshTissue Distributionen
dc.titleGallium-68-labeled anti-HER2 single-chain Fv fragment: development and in vivo monitoring of HER2 expression.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA1170000X-
dc.identifier.jtitleMolecular imaging and biologyen
dc.identifier.volume17-
dc.identifier.issue1-
dc.identifier.spage102-
dc.identifier.epage110-
dc.relation.doi10.1007/s11307-014-0769-5-
dc.textversionauthor-
dc.startdate.bitstreamsavailable2015-07-22-
dc.identifier.pmid25049073-
dcterms.accessRightsopen access-
dc.identifier.pissn1536-1632-
dc.identifier.eissn1860-2002-
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