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dc.contributor.author | Ueda, Masashi | en |
dc.contributor.author | Hisada, Hayato | en |
dc.contributor.author | Temma, Takashi | en |
dc.contributor.author | Shimizu, Yoichi | en |
dc.contributor.author | Kimura, Hiroyuki | en |
dc.contributor.author | Ono, Masahiro | en |
dc.contributor.author | Nakamoto, Yuji | en |
dc.contributor.author | Togashi, Kaori | en |
dc.contributor.author | Saji, Hideo | en |
dc.contributor.alternative | 上田, 真史 | ja |
dc.contributor.alternative | 佐治, 英郎 | ja |
dc.date.accessioned | 2015-12-08T06:03:07Z | - |
dc.date.available | 2015-12-08T06:03:07Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1536-1632 | - |
dc.identifier.uri | http://hdl.handle.net/2433/202106 | - |
dc.description | First online: 22 July 2014 | en |
dc.description.abstract | 【Purpose】We aimed to develop a gallium-68 (Ga-68)-labeled single-chain variable fragment (scFv) targeting the human epidermal growth factor receptor 2 (HER2) to rapidly and noninvasively evaluate the status of HER2 expression. 【Procedures】Anti-HER2 scFv was labeled with Ga-68 by using deferoxamine (Df) as a bifunctional chelate. Biodistribution of [(68)Ga]Df-anti-HER2 scFv was examined with tumor-bearing mice and positron emission tomography (PET) imaging was performed. The changes in HER2 expression after anti-HER2 therapy were monitored by PET imaging. 【Results】[(68)Ga]Df-anti-HER2 scFv was obtained with high radiochemical yield after only a 5-min reaction at room temperature. The probe showed high accumulation in HER2-positive xenografts and the intratumoral distribution of radioactivity coincided with HER2-positive regions. Furthermore, [(68)Ga]Df-anti-HER2 scFv helped visualize HER2-positive xenografts and monitor the changes in HER2 expression after anti-HER2 therapy.【Conclusion】[(68)Ga]Df-anti-HER2 scFv could be a promising probe to evaluate HER2 status by in vivoPET imaging, unless trastuzumab is prescribed as part of the therapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer | en |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s11307-014-0769-5. | en |
dc.rights | The full-text file will be made open to the public on 22 July 2015 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Cell Line, Tumor | en |
dc.subject.mesh | Chelating Agents/chemistry | en |
dc.subject.mesh | Deferoxamine/chemistry | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Gallium/chemistry | en |
dc.subject.mesh | Gallium Radioisotopes/chemistry | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Immunohistochemistry | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred BALB C | en |
dc.subject.mesh | Neoplasm Transplantation | en |
dc.subject.mesh | Positron-Emission Tomography | en |
dc.subject.mesh | Radiopharmaceuticals/chemistry | en |
dc.subject.mesh | Receptor, ErbB-2/metabolism | en |
dc.subject.mesh | Single-Chain Antibodies/chemistry | en |
dc.subject.mesh | Tissue Distribution | en |
dc.title | Gallium-68-labeled anti-HER2 single-chain Fv fragment: development and in vivo monitoring of HER2 expression. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA1170000X | - |
dc.identifier.jtitle | Molecular imaging and biology | en |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 102 | - |
dc.identifier.epage | 110 | - |
dc.relation.doi | 10.1007/s11307-014-0769-5 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-07-22 | - |
dc.identifier.pmid | 25049073 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 1536-1632 | - |
dc.identifier.eissn | 1860-2002 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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