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Title: Final-Stage Site-Selective Acylation for the Total Syntheses of Multifidosides A-C.
Authors: Ueda, Yoshihiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5485-2722 (unconfirmed)
Furuta, Takumi
Kawabata, Takeo  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9959-0420 (unconfirmed)
Author's alias: 川端, 猛夫
Keywords: acylation
glycosides
natural products
organocatalysis
synthetic methods
Issue Date: 5-Oct-2015
Publisher: wiley
Journal title: Angewandte Chemie: International Edition
Volume: 54
Issue: 41
Start page: 11966
End page: 11970
Abstract: The first total syntheses of multifidosides A-C have been achieved. The synthetic strategy is characterized by catalytic site-selective acylation of unprotected glycoside precursors in the final stage of the synthesis. High functional-group tolerance of the site-selective acylation, promoted by an organocatalyst, enabled the conventionally difficult molecular transformation in a predictable and reliable manner. An advantage of this strategy is to avoid the risks of undesired side reactions during the removal of the protecting groups at the final stage of the total synthesis.
Description: Article first published online: 28 AUG 2015
Rights: This is the peer reviewed version of the following article: Ueda, Y., Furuta, T. and Kawabata, T. (2015), Final-Stage Site-Selective Acylation for the Total Syntheses of Multifidosides A–C. Angew. Chem. Int. Ed., 54: 11966–11970, which has been published in final form at http://dx.doi.org/10.1002/anie.201504729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 28 AUG 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/202609
DOI(Published Version): 10.1002/anie.201504729
PubMed ID: 26384855
Appears in Collections:Journal Articles

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