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1.JBO.20.9.096006.pdf2.27 MBAdobe PDF見る/開く
タイトル: Development of photostabilized asymmetrical cyanine dyes for in vivo photoacoustic imaging of tumors.
著者: Onoe, Satoru
Temma, Takashi
Kanazaki, Kengo
Ono, Masahiro  kyouindb  KAKEN_id
Saji, Hideo
著者名の別形: 天満, 敬
佐治, 英郎
キーワード: triplet-state quencher
near-infrared
photoacoustic imaging
optical imaging
albumin binding
cancer diagnosis
発行日: Sep-2015
出版者: Society of Photo-Optical Instrumentation Engineers(SPIE)
誌名: Journal of biomedical optics
巻: 20
号: 9
論文番号: 096006
抄録: Photoacoustic imaging (PAI) contributes to tumor diagnosis through the use of PAI probes that effectively accumulate in tumors. Previously, we developed a symmetrical cyanine dye, IC7-1-Bu, which showed high potential as a PAI probe because of its high tumor targeting ability and sufficient in vivo PA signal. However, IC7-1-Bu lacks photostability for multiple laser irradiations, so we developed stabilized PAI probes using IC7-1-Bu as a lead compound. We focused on the effect of singlet oxygen (1O2) generated by excited PAI probes on probe degeneration. We introduced a triplet-state quencher (TSQ) moiety into IC7-1-Bu to quench 1O2 generation and designed three IC-n-T derivatives with different linker lengths (n indicates linker length). The IC-n-T derivatives emitted in vitro PA signals that were comparable to IC7-1-Bu and significantly reduced 1O2 generation while showing improved photostability against multiple irradiations. Of the three derivatives evaluated, IC-5-T accumulated in tumors effectively to allow clear PAI of tumors in vivo. Furthermore, the photostability of IC-5-T was 1.5-fold higher than that of IC7-1-Bu in in vivo sequential PAI. These results suggest that IC-5-T is a potential PAI probe for in vivo sequential tumor imaging.
著作権等: Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
URI: http://hdl.handle.net/2433/202623
DOI(出版社版): 10.1117/1.JBO.20.9.096006
PubMed ID: 26358819
出現コレクション:学術雑誌掲載論文等

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