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ファイル | 記述 | サイズ | フォーマット | |
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1.JBO.20.9.096006.pdf | 2.27 MB | Adobe PDF | 見る/開く |
タイトル: | Development of photostabilized asymmetrical cyanine dyes for in vivo photoacoustic imaging of tumors. |
著者: | Onoe, Satoru Temma, Takashi Kanazaki, Kengo Ono, Masahiro https://orcid.org/0000-0002-2497-039X (unconfirmed) Saji, Hideo |
著者名の別形: | 天満, 敬 佐治, 英郎 |
キーワード: | triplet-state quencher near-infrared photoacoustic imaging optical imaging albumin binding cancer diagnosis |
発行日: | Sep-2015 |
出版者: | Society of Photo-Optical Instrumentation Engineers(SPIE) |
誌名: | Journal of biomedical optics |
巻: | 20 |
号: | 9 |
論文番号: | 096006 |
抄録: | Photoacoustic imaging (PAI) contributes to tumor diagnosis through the use of PAI probes that effectively accumulate in tumors. Previously, we developed a symmetrical cyanine dye, IC7-1-Bu, which showed high potential as a PAI probe because of its high tumor targeting ability and sufficient in vivo PA signal. However, IC7-1-Bu lacks photostability for multiple laser irradiations, so we developed stabilized PAI probes using IC7-1-Bu as a lead compound. We focused on the effect of singlet oxygen (1O2) generated by excited PAI probes on probe degeneration. We introduced a triplet-state quencher (TSQ) moiety into IC7-1-Bu to quench 1O2 generation and designed three IC-n-T derivatives with different linker lengths (n indicates linker length). The IC-n-T derivatives emitted in vitro PA signals that were comparable to IC7-1-Bu and significantly reduced 1O2 generation while showing improved photostability against multiple irradiations. Of the three derivatives evaluated, IC-5-T accumulated in tumors effectively to allow clear PAI of tumors in vivo. Furthermore, the photostability of IC-5-T was 1.5-fold higher than that of IC7-1-Bu in in vivo sequential PAI. These results suggest that IC-5-T is a potential PAI probe for in vivo sequential tumor imaging. |
著作権等: | Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. |
URI: | http://hdl.handle.net/2433/202623 |
DOI(出版社版): | 10.1117/1.JBO.20.9.096006 |
PubMed ID: | 26358819 |
出現コレクション: | 学術雑誌掲載論文等 |
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