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dc.contributor.authorTakahashi, Haruyaja
dc.contributor.authorKamakari, Kosukeja
dc.contributor.authorGoto, Tsuyoshija
dc.contributor.authorHara, Hideyukija
dc.contributor.authorMohri, Shinsukeja
dc.contributor.authorSuzuki, Hideyukija
dc.contributor.authorShibata, Daisukeja
dc.contributor.authorNakata, Riekoja
dc.contributor.authorInoue, Hiroyasuja
dc.contributor.authorTakahashi, Nobuyukija
dc.contributor.authorKawada, Teruoja
dc.contributor.alternative高橋, 春弥ja
dc.contributor.alternative河田, 照雄ja
dc.date.accessioned2016-01-13T07:30:03Z-
dc.date.available2016-01-13T07:30:03Z-
dc.date.issued2015-11ja
dc.identifier.issn0024-4201ja
dc.identifier.urihttp://hdl.handle.net/2433/203050-
dc.descriptionFirst online: 19 September 2015ja
dc.description.abstractThe peroxisome proliferator-activated receptor (PPAR)α is mainly expressed in the liver and plays an important role in the regulation of lipid metabolism. It has been reported that PPARα activation enhances fatty acid oxidation and reduces fat storage. Therefore, PPARα agonists are used to treat dyslipidemia. In the present study, we found that 9-oxo-10(E), 12(Z), 15(Z)-octadecatrienoic acid (9-oxo-OTA), which is a α-linolenic acid (ALA) derivative, is present in tomato (Solanum lycopersicum) extract. We showed that 9-oxo-OTA activated PPARα and induced the mRNA expression of PPARα target genes in murine primary hepatocytes. These effects promoted fatty acid uptake and the secretion of β-hydroxybutyrate, which is one of the endogenous ketone bodies. We also demonstrated that these effects of 9-oxo-OTA were not observed in PPARα-knockout (KO) primary hepatocytes. To our knowledge, this is the first study to report that 9-oxo-OTA promotes fatty acid metabolism via PPARα activation and discuss its potential as a valuable food-derived compound for use in the management of dyslipidemia.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherSpringer Berlin Heidelbergja
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s11745-015-4071-3.ja
dc.rightsThe full-text file will be made open to the public on 19 September 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.ja
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.subjectPPARαja
dc.subjectOxylipinja
dc.subjectHepatocytesja
dc.subjectFatty acid metabolismja
dc.subjectLC–MSja
dc.title9-Oxo-10(E),12(Z),15(Z)-Octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor α in Hepatocytes.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA00275467ja
dc.identifier.jtitleLipidsja
dc.identifier.volume50ja
dc.identifier.issue11ja
dc.identifier.spage1083ja
dc.identifier.epage1091ja
dc.relation.doi10.1007/s11745-015-4071-3ja
dc.textversionauthorja
dc.startdate.bitstreamsavailable2016-09-19ja
dc.identifier.pmid26387026ja
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