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タイトル: | Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes. |
著者: | Nanthirudjanar, Tharnath Furumoto, Hidehiro Zheng, Jiawen Kim, Young-Il Goto, Tsuyoshi https://orcid.org/0000-0003-1283-147X (unconfirmed) Takahashi, Nobuyuki Kawada, Teruo Park, Si-Bum Hirata, Akiko Kitamura, Nahoko Kishino, Shigenobu https://orcid.org/0000-0002-4587-2422 (unconfirmed) Ogawa, Jun https://orcid.org/0000-0003-2741-621X (unconfirmed) Hirata, Takashi Sugawara, Tatsuya https://orcid.org/0000-0002-1203-5521 (unconfirmed) |
著者名の別形: | 菅原, 達也 |
キーワード: | Acetyl-CoA carboxylase Hydroxy fatty acid Oxo fatty acid Lipogenesis Liver Sterol regulatory element binding protein-1c |
発行日: | Nov-2015 |
出版者: | Springer Berlin Heidelberg |
誌名: | Lipids |
巻: | 50 |
号: | 11 |
開始ページ: | 1093 |
終了ページ: | 1102 |
抄録: | Hydroxy and oxo fatty acids were recently found to be produced as intermediates during gut microbial fatty acid metabolism. Lactobacillus plantarum produces these fatty acids from unsaturated fatty acids such as linoleic acid. In this study, we investigated the effects of these gut microbial fatty acid metabolites on the lipogenesis in liver cells. We screened their effect on sterol regulatory element binding protein-1c (SREBP-1c) expression in HepG2 cells treated with a synthetic liver X receptor α (LXRα) agonist (T0901317). The results showed that 10-hydroxy-12(Z)-octadecenoic acid (18:1) (HYA), 10-hydroxy-6(Z), 12(Z)-octadecadienoic acid (18:2) (γHYA), 10-oxo-12(Z)-18:1 (KetoA), and 10-oxo-6(Z), 12(Z)-18:2 (γKetoA) significantly decreased SREBP-1c mRNA expression induced by T0901317. These fatty acids also downregulated the mRNA expression of lipogenic genes by suppressing LXRα activity and inhibiting SREBP-1 maturation. Oral administration of KetoA, which effectively reduced triacylglycerol accumulation and acetyl-CoA carboxylase 2 (ACC2) expression in HepG2 cells, for 2 weeks significantly decreased Srebp-1c, Scd-1, and Acc2 expression in the liver of mice fed a high-sucrose diet. Our findings suggest that the hypolipidemic effect of the fatty acid metabolites produced by L. plantarum can be exploited in the treatment of cardiovascular diseases or dyslipidemia. |
記述: | First online: 23 September 2015 |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s11745-015-4067-z. The full-text file will be made open to the public on 23 September 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/203067 |
DOI(出版社版): | 10.1007/s11745-015-4067-z |
PubMed ID: | 26399511 |
出現コレクション: | 学術雑誌掲載論文等 |
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