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タイトル: | <Original Articles>Study of Effect of Surgical Stress on Immunity in Patients with Gastrointestinal Cancer |
その他のタイトル: | <原著>外科侵襲が消化器癌患者の免疫能にあたえる影響に関する検討 |
著者: | TANABE, HIROSHI |
著者名の別形: | 田辺, 博 |
キーワード: | Gastrointestinal cancer Surgical stress Immune activity Lymphocyte subsets Three color flow cytometry 胃癌 外科侵襲 免疫能リンパ球サブセット three color flow cytometry |
発行日: | 1-May-1993 |
出版者: | 京都大学医学部外科整形外科学教室内 日本外科宝函編集室 |
誌名: | 日本外科宝函 |
巻: | 62 |
号: | 3 |
開始ページ: | 145 |
終了ページ: | 152 |
抄録: | We investigated the effect of surgical stress on immunity in patients with gastrointestinal cancer by three color flow cytometry centering on lymphocyte subsets. The control group consisted of patients with cholelithiasis as a benign disease and the cancer groups consisted of patients with gastric cancer and those with colorectal cancer. Total lymphocyte in peripheral blood, lymphocyte subsets by monoclonal antibody and NK cell activity were measured before and after operation in the target patients. The cell ratio of CD4_+CD45R_+Leu8_+(suppressor inducer T), CD8_+CDllb_+(suppressor T) were significantly higher in the gastrointestinal cancer group when lymphocyte subsets were investigated after operation. Further, the cell ratio of CD3_+CD16_-CD56_+(T-LAK) was significantly lower . These findings suggest that decrease in immunity as a result of surgical stress is greater in patients with gastrointestinal cancer than in those with a benign disease. |
URI: | http://hdl.handle.net/2433/203680 |
PubMed ID: | 8274052 |
出現コレクション: | 第62巻 第3号 |
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