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Title: 治療に難渋したビスホスホネート関連顎骨壊死の1例
Other Titles: A Case of Bisphosphonate-Related Osteonecrosis of the Jaw with Difficulty in Treatment
Authors: 中村, 健治  KAKEN_name
福本, 哲也  KAKEN_name
福井, 智洋  KAKEN_name
酒谷, 徹  KAKEN_name
熱田, 雄  KAKEN_name
加藤, 琢磨  KAKEN_name
伊藤, 将彰  KAKEN_name
井上, 幸治  KAKEN_name
寺井, 章人  KAKEN_name
Author's alias: Nakamura, Kenji
Fukumoto, Tetsuya
Fukui, Tomohiro
Sakatani, Toru
Atsuta, Takeshi
Kato, Takuma
Ito, Masaaki
Inoue, Koji
Terai, Akito
Keywords: Bisphosphonate-relatedosteonecrosis of the jaw
Prostate cancer
Issue Date: 31-Jan-2016
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 62
Issue: 1
Start page: 39
End page: 44
Abstract: A 65-year-oldman with urination difficulty visited our hospital. Because his prostate-specific antigen level was 1, 619 ng/ml, we performeda prostate biopsy. The biopsy specimen yielded a diagnosis of adenocarcinoma with a Gleason score of 4+4. Computedtomography and bone scintigraphy showed lymph node, lung, and bone metastasis (cT3bN1M1). After 13 months of combined androgen blockade, he underwent treatment with a bisphosphonate. At 22 months of treatment, he developed bisphosphonaterelated osteonecrosis of the jaw, andall necrotic bone and teeth were removed. He subsequently underwent repeated cleaning and fixation (splinting) for an oral fistula andmand ibular fracture. Emergency transcatheter arterial embolization was then performed to treat a bleeding of the facial artery aneurysm. An oral infection and aspiration pneumonia repeatedly developed secondary to the oral fistula. The patient underwent a gastrostomy, after which his nutritional status improved and he was discharged.
Rights: 許諾条件により本文は2017/02/01に公開
PubMed ID: 26932335
Appears in Collections:Vol.62 No.1

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