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DCフィールド | 値 | 言語 |
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dc.contributor.author | Tsukano, Chihiro | en |
dc.contributor.author | Yamamoto, Sho | en |
dc.contributor.author | Takemoto, Yoshiji | en |
dc.contributor.alternative | 塚野, 千尋 | ja |
dc.contributor.alternative | 竹本, 佳司 | ja |
dc.date.accessioned | 2016-03-02T06:38:29Z | - |
dc.date.available | 2016-03-02T06:38:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | http://hdl.handle.net/2433/207633 | - |
dc.description.abstract | The synthesis of α-acyloxyketones via the migration of a propargylic ester followed by the intramolecular nucleophilic addition of the resulting allene was achieved using a cationic platinum catalyst. The optimized conditions for this transformation were determined to be 3 mol% of Pt(cod)Cl[2], 3 mol% of AgNTf[2], and 3 eq of water in toluene at 100 °C, and these conditions were successfully applied to the synthesis of a wide variety of α-aryl-α-acyloxyketones. The mechanism of this reaction was evaluated in detail based on the results of isotope labeling experiments using H[2](18)O. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Pharmaceutical Society of Japan | en |
dc.publisher.alternative | 日本薬学会 | ja |
dc.rights | © 2015 The Pharmaceutical Society of Japan | en |
dc.subject | platinum | en |
dc.subject | propargylic ester migration | en |
dc.subject | α-acyloxyketone | en |
dc.title | Synthesis of α-Acyloxyketone Derivatives via the Platinum-Catalyzed Migration of Propargylic Esters. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00602100 | - |
dc.identifier.jtitle | Chemical & pharmaceutical bulletin | en |
dc.identifier.volume | 63 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 710 | - |
dc.identifier.epage | 719 | - |
dc.relation.doi | 10.1248/cpb.c15-00417 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 26329864 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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