ダウンロード数: 301
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
cpb.c15-00365.pdf | 767.3 kB | Adobe PDF | 見る/開く |
タイトル: | Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[11C]Methylation with [11C]CH3I: Rapid Synthesis of [11C]Raclopride. |
著者: | Kawashima, Hidekazu Kimura, Hiroyuki Nakaya, Yuta Tomatsu, Kenji Arimitsu, Kenji Nakanishi, Hiroaki Ozeki, Eiichi Kuge, Yuji Saji, Hideo |
著者名の別形: | 佐治, 英郎 |
キーワード: | microreactor [11C]raclopride O-[11C]methylation [11C]CH3I positron emission tomography |
発行日: | 2015 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Chemical & pharmaceutical bulletin |
巻: | 63 |
号: | 9 |
開始ページ: | 737 |
終了ページ: | 740 |
抄録: | A new radiolabeling method using a microreactor was developed for the rapid synthesis of [(11)C]raclopride. A chip bearing a Y-shaped mixing junction with a 200 µm (width)×20 µm (depth)×250 mm (length) flow channel was designed, and the efficiency of O-[11C]methylation was evaluated. Dimethyl sulfoxide solutions containing the O-desmethyl precursor or [11C]CH3I were introduced into separate injection ports by infusion syringes, and the radiochemical yields were measured under various conditions. The decay-corrected radiochemical yield of microreactor-derived [11C]raclopride reached 12% in 20 s at 25 °C, which was observed to increase with increasing temperature. In contrast, batch synthesis at 25 °C produced a yield of 5%: this indicates that this device could effectively achieve O-[11C]methylation in a shorter period of time. The microreactor technique may facilitate simple and efficient routine production of 11C-labeled compounds via O-[11C]methylation with [11C]CH3I. |
著作権等: | © 2015 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/207680 |
DOI(出版社版): | 10.1248/cpb.c15-00365 |
PubMed ID: | 26329868 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。