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タイトル: | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. |
著者: | Yahara, Yasuhito Takemori, Hiroshi Okada, Minoru Kosai, Azuma Yamashita, Akihiro Kobayashi, Tomohito Fujita, Kaori Itoh, Yumi Nakamura, Masahiro Fuchino, Hiroyuki Kawahara, Nobuo Fukui, Naoshi Watanabe, Akira Kimura, Tomoatsu Tsumaki, Noriyuki https://orcid.org/0000-0002-0520-3654 (unconfirmed) |
著者名の別形: | 箭原, 康人 竹森, 洋 妻木, 範行 |
キーワード: | Biological sciences Medical research |
発行日: | 24-Mar-2016 |
出版者: | Nature Publishing Group |
誌名: | Nature communications |
巻: | 7 |
論文番号: | 10959 |
抄録: | Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic. |
記述: | 植物由来成分であるプテロシンBはSIK3を阻害し変形性関節症の治療薬開発のリード化合物となる. 京都大学プレスリリース. 2016-03-31. Yahara, Y., Takemori, H., Okada, M. et al. Correction: Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun 7, 12117 (2016). |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/210029 |
DOI(出版社版): | 10.1038/ncomms10959 |
PubMed ID: | 27009967 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-03-31-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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