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ncomms10767.pdf | 2.41 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Merlevede, Jane | en |
dc.contributor.author | Droin, Nathalie | en |
dc.contributor.author | Qin, Tingting | en |
dc.contributor.author | Meldi, Kristen | en |
dc.contributor.author | Yoshida, Kenichi | en |
dc.contributor.author | Morabito, Margot | en |
dc.contributor.author | Chautard, Emilie | en |
dc.contributor.author | Auboeuf, Didier | en |
dc.contributor.author | Fenaux, Pierre | en |
dc.contributor.author | Braun, Thorsten | en |
dc.contributor.author | Itzykson, Raphael | en |
dc.contributor.author | De Botton, Stéphane | en |
dc.contributor.author | Quesnel, Bruno | en |
dc.contributor.author | Commes, Thérèse | en |
dc.contributor.author | Jourdan, Eric | en |
dc.contributor.author | Vainchenker, William | en |
dc.contributor.author | Bernard, Olivier | en |
dc.contributor.author | Pata-Merci, Noemie | en |
dc.contributor.author | Solier, Stéphanie | en |
dc.contributor.author | Gayevskiy, Velimir | en |
dc.contributor.author | Dinger, Marcel E. | en |
dc.contributor.author | Cowley, Mark J. | en |
dc.contributor.author | Selimoglu-Buet, Dorothée | en |
dc.contributor.author | Meyer, Vincent | en |
dc.contributor.author | Artiguenave, François | en |
dc.contributor.author | Deleuze, Jean François | en |
dc.contributor.author | Preudhomme, Claude | en |
dc.contributor.author | Stratton, Michael R. | en |
dc.contributor.author | Alexandrov, Ludmil B. | en |
dc.contributor.author | Padron, Eric | en |
dc.contributor.author | Ogawa, Seishi | en |
dc.contributor.author | Koscielny, Serge | en |
dc.contributor.author | Figueroa, Maria | en |
dc.contributor.author | Solary, Eric | en |
dc.contributor.alternative | 小川, 誠司 | ja |
dc.date.accessioned | 2016-04-14T04:59:58Z | - |
dc.date.available | 2016-04-14T04:59:58Z | - |
dc.date.issued | 2016-02-24 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2433/210212 | - |
dc.description.abstract | The cytidine analogues azacytidine and 5-aza-2′ -deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a comprehensive analysis of the mutational landscape of these tumours, combining whole-exome and whole-genome sequencing. We identify an average of 14±5 somatic mutations in coding sequences of sorted monocyte DNA and the signatures of three mutational processes. Serial sequencing demonstrates that the response to hypomethylating agents is associated with changes in DNA methylation and gene expression, without any decrease in the mutation allele burden, nor prevention of new genetic alteration occurence. Our findings indicate that cytosine analogues restore a balanced haematopoiesis without decreasing the size of the mutated clone, arguing for a predominantly epigenetic effect. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Biological sciences | en |
dc.subject | Cancer | en |
dc.subject | Genetics | en |
dc.title | Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature Communications | en |
dc.identifier.volume | 7 | - |
dc.relation.doi | 10.1038/ncomms10767 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 10767 | - |
dc.identifier.pmid | 26908133 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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