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j.cortex.2014.11.008.pdf | 3.87 MB | Adobe PDF | 見る/開く |
タイトル: | Neural correlates of mirth and laughter: a direct electrical cortical stimulation study. |
著者: | Yamao, Yukihiro https://orcid.org/0000-0002-9615-2353 (unconfirmed) Matsumoto, Riki https://orcid.org/0000-0003-3985-9210 (unconfirmed) Kunieda, Takeharu Shibata, Sumiya Shimotake, Akihiro Kikuchi, Takayuki Satow, Takeshi Mikuni, Nobuhiro Fukuyama, Hidenao Ikeda, Akio https://orcid.org/0000-0002-0790-2598 (unconfirmed) Miyamoto, Susumu |
著者名の別形: | 山尾, 幸広 松本, 理器 國枝, 武治 芝田, 純也 下竹, 昭寛 菊池, 隆幸 佐藤, 岳史 三國, 信啓 福山, 秀直 池田, 昭夫 宮本, 享 |
キーワード: | Mirth Laughter Electrical cortical stimulation Mesial temporal structure Basal temporal language area |
発行日: | May-2015 |
出版者: | Elsevier Ltd. |
誌名: | Cortex |
巻: | 66 |
開始ページ: | 134 |
終了ページ: | 140 |
抄録: | Laughter consists of both motor and emotional aspects. The emotional component, known as mirth, is usually associated with the motor component, namely, bilateral facial movements. Previous electrical cortical stimulation (ES) studies revealed that mirth was associated with the basal temporal cortex, inferior frontal cortex, and medial frontal cortex. Functional neuroimaging implicated a role for the left inferior frontal and bilateral temporal cortices in humor processing. However, the neural origins and pathways linking mirth with facial movements are still unclear. We hereby report two cases with temporal lobe epilepsy undergoing subdural electrode implantation in whom ES of the left basal temporal cortex elicited both mirth and laughter-related facial muscle movements. In one case with normal hippocampus, high-frequency ES consistently caused contralateral facial movement, followed by bilateral facial movements with mirth. In contrast, in another case with hippocampal sclerosis (HS), ES elicited only mirth at low intensity and short duration, and eventually laughter at higher intensity and longer duration. In both cases, the basal temporal language area (BTLA) was located within or adjacent to the cortex where ES produced mirth. In conclusion, the present direct ES study demonstrated that 1) mirth had a close relationship with language function, 2) intact mesial temporal structures were actively engaged in the beginning of facial movements associated with mirth, and 3) these emotion-related facial movements had contralateral dominance. |
著作権等: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/210373 |
DOI(出版社版): | 10.1016/j.cortex.2014.11.008 |
PubMed ID: | 25534936 |
出現コレクション: | 学術雑誌掲載論文等 |
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