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Title: Neural correlates of mirth and laughter: a direct electrical cortical stimulation study.
Authors: Yamao, Yukihiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9615-2353 (unconfirmed)
Matsumoto, Riki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-3985-9210 (unconfirmed)
Kunieda, Takeharu
Shibata, Sumiya
Shimotake, Akihiro  kyouindb  KAKEN_id
Kikuchi, Takayuki  kyouindb  KAKEN_id
Satow, Takeshi
Mikuni, Nobuhiro
Fukuyama, Hidenao
Ikeda, Akio
Miyamoto, Susumu
Author's alias: 山尾, 幸広
松本, 理器
國枝, 武治
芝田, 純也
下竹, 昭寛
菊池, 隆幸
佐藤, 岳史
三國, 信啓
福山, 秀直
池田, 昭夫
宮本, 享
Keywords: Mirth
Laughter
Electrical cortical stimulation
Mesial temporal structure
Basal temporal language area
Issue Date: May-2015
Publisher: Elsevier Ltd.
Journal title: Cortex
Volume: 66
Start page: 134
End page: 140
Abstract: Laughter consists of both motor and emotional aspects. The emotional component, known as mirth, is usually associated with the motor component, namely, bilateral facial movements. Previous electrical cortical stimulation (ES) studies revealed that mirth was associated with the basal temporal cortex, inferior frontal cortex, and medial frontal cortex. Functional neuroimaging implicated a role for the left inferior frontal and bilateral temporal cortices in humor processing. However, the neural origins and pathways linking mirth with facial movements are still unclear. We hereby report two cases with temporal lobe epilepsy undergoing subdural electrode implantation in whom ES of the left basal temporal cortex elicited both mirth and laughter-related facial muscle movements. In one case with normal hippocampus, high-frequency ES consistently caused contralateral facial movement, followed by bilateral facial movements with mirth. In contrast, in another case with hippocampal sclerosis (HS), ES elicited only mirth at low intensity and short duration, and eventually laughter at higher intensity and longer duration. In both cases, the basal temporal language area (BTLA) was located within or adjacent to the cortex where ES produced mirth. In conclusion, the present direct ES study demonstrated that 1) mirth had a close relationship with language function, 2) intact mesial temporal structures were actively engaged in the beginning of facial movements associated with mirth, and 3) these emotion-related facial movements had contralateral dominance.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 1 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/210373
DOI(Published Version): 10.1016/j.cortex.2014.11.008
PubMed ID: 25534936
Appears in Collections:Journal Articles

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