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dc.contributor.authorIwata, Toshiyukien
dc.contributor.authorIto, Isaoen
dc.contributor.authorNiimi, Akioen
dc.contributor.authorIkegami, Kojien
dc.contributor.authorMarumo, Satoshien
dc.contributor.authorTanabe, Naoyaen
dc.contributor.authorNakaji, Hitoshien
dc.contributor.authorKanemitsu, Yoshihiroen
dc.contributor.authorMatsumoto, Hisakoen
dc.contributor.authorKamei, Junzoen
dc.contributor.authorSetou, Mitsutoshien
dc.contributor.authorMishima, Michiakien
dc.contributor.alternative伊藤, 功朗ja
dc.contributor.alternative松本, 久子ja
dc.contributor.alternative三嶋, 理晃ja
dc.contributor.transcriptionイトウ, イサオja
dc.contributor.transcriptionマツモト, ヒサコja
dc.contributor.transcriptionミシマ, ミチアキja
dc.date.accessioned2016-04-26T05:39:14Z-
dc.date.available2016-04-26T05:39:14Z-
dc.date.issued2015-11-18-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2433/210376-
dc.description.abstractCough affects all individuals at different times, and its economic burden is substantial. Despite these widespread adverse effects, cough research relies on animal models, which hampers our understanding of the fundamental cause of cough. Postnasal drip is speculated to be one of the most frequent causes of chronic cough; however, this is a matter of debate. Here we show that mechanical stimuli by postnasal drip cause chronic cough. We distinguished human cough from sneezes and expiration reflexes by airflow patterns. Cough and sneeze exhibited one-peak and two-peak patterns, respectively, in expiratory airflow, which were also confirmed by animal models of cough and sneeze. Transgenic mice with ciliary dyskinesia coughed substantially and showed postnasal drip in the pharynx; furthermore, their cough was completely inhibited by nasal airway blockade of postnasal drip. We successfully reproduced cough observed in these mice by injecting artificial postnasal drip in wild-type mice. These results demonstrated that mechanical stimulation by postnasal drip evoked cough. The findings of our study can therefore be used to develop new antitussive drugs that prevent the root cause of cough.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Iwata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.titleMechanical stimulation by postnasal drip evokes coughen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitlePLOS ONEen
dc.identifier.volume10-
dc.identifier.issue11-
dc.relation.doi10.1371/journal.pone.0141823-
dc.textversionpublisher-
dc.identifier.artnume0141823-
dc.identifier.pmid26581078-
dcterms.accessRightsopen access-
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