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dc.contributor.author | Kim, Chu Sook | en |
dc.contributor.author | Kwon, Yoonhee | en |
dc.contributor.author | Choe, Suck Young | en |
dc.contributor.author | Hong, Sun Myung | en |
dc.contributor.author | Yoo, Hoon | en |
dc.contributor.author | Goto, Tsuyoshi | en |
dc.contributor.author | Kawada, Teruo | en |
dc.contributor.author | Choi, Hye Seon | en |
dc.contributor.author | Joe, Yeonsoo | en |
dc.contributor.author | Chung, Hun Taeg | en |
dc.contributor.author | Yu, Rina | en |
dc.contributor.alternative | 後藤, 剛 | ja |
dc.contributor.alternative | 河田, 照雄 | ja |
dc.date.accessioned | 2016-05-24T02:47:58Z | - |
dc.date.available | 2016-05-24T02:47:58Z | - |
dc.date.issued | 2015-10-06 | - |
dc.identifier.issn | 1743-7075 | - |
dc.identifier.uri | http://hdl.handle.net/2433/212478 | - |
dc.description.abstract | Background: Obesity-induced hepatic lipid accumulation causes lipotoxicity, mitochondrial dysfunction, oxidative stress, and insulin resistance, and is implicated in non-alcoholic hepatic pathologies such as steatohepatitis and fibrosis. Heme oxygenase-1 (HO-1), an important antioxidant enzyme catalyzing the rate-limiting step in heme degradation, protects against oxidative stress, inflammation, and metabolic dysregulation. Here, we demonstrate that the phytochemical, quercetin, a natural polyphenol flavonoid, protects against hepatic steatosis in obese mice fed a high-fat diet, and that it does so by inducing HO-1 and stimulating increased hepatic mitochondrial oxidative metabolism. Methods: Male C57BL/6 mice were fed a regular diet (RD), a high-fat diet (HFD), and an HFD supplemented with quercetin for 9 weeks. Levels of mitochondrial biogenesis and oxidative metabolic transcripts/proteins were measured by real-time PCR and/or Western blotting. HO-1 transcripts/proteins were measured real-time PCR and/or Western blotting. Results: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein. The HO-1 inducer hemin and the HO-1 byproduct carbon monoxide (CO) also enhanced hepatic oxidative metabolism in HFD-fed obese mice. Moreover, the metabolic changes and the lipid-lowering effects of quercetin were completely blocked by the HO-1 inhibitor ZnPP and by deficiency of Nrf-2. Conclusion: These findings suggest that quercetin stimulates hepatic mitochondrial oxidative metabolism by inducing HO-1 via the Nrf-2 pathway. Quercetin may be useful in protecting against obesity-induced hepatosteatosis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central Ltd. | en |
dc.rights | © 2015 Kim et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.subject | Obesity | en |
dc.subject | Hepatosteatosis | en |
dc.subject | Fatty liver disease | en |
dc.subject | Mitochondrial oxidative metabolism | en |
dc.title | Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1 | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nutrition and Metabolism | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.1186/s12986-015-0030-5 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 33 | - |
dc.identifier.pmid | 26445592 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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