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Title: Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface
Authors: Nishigami, Yukinori
Ito, Hiroaki
Sonobe, Seiji
Ichikawa, Masatoshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-6345-2106 (unconfirmed)
Author's alias: 西上, 幸範
伊藤, 弘明
市川, 正敏
Issue Date: 12-Jan-2016
Publisher: Nature Publishing Group
Journal title: Scientific Reports
Volume: 6
Thesis number: 18964
Abstract: Active force generation in living organisms, which is mainly involved in actin cytoskeleton and myosin molecular motors, plays a crucial role in various biological processes. Although the contractile properties of actomyosin have been extensively investigated, their dynamic contribution to a deformable membrane remains unclear because of the cellular complexities and the difficulties associated with in vitro reconstitution. Here, by overcoming these experimental difficulties, we demonstrate the dynamic deformation of a reconstituted lipid interface coupled with self-organized structure of contractile actomyosin. Therein, the lipid interface repeatedly oscillates without any remarkable periods. The oscillatory deformation of the interface is caused by the aster-like three-dimensional hierarchical structure of actomyosin inside the droplet, which is revealed that the oscillation occurs stochastically as a Poisson process.
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/2433/212498
DOI(Published Version): 10.1038/srep18964
PubMed ID: 26754862
Appears in Collections:Journal Articles

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