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Title: Association between shift work and the risk of death from biliary tract cancer in Japanese men
Authors: Lin, Yingsong
Nishiyama, Takeshi
Kurosawa, Michiko
Tamakoshi, Akiko
Kubo, Tatsuhiko
Fujino, Yoshihisa
Kikuchi, Shogo
Tamakoshi, Akiko
Mori, Mitsuru
Sakauchi, Fumio
Motohashi, Yutaka
Tsuji, Ichiro
Nakamura, Yosikazu
Iso, Hiroyasu
Mikami, Haruo
Hoshiyama, Yoshiharu
Tanabe, Naohito
Wakai, Kenji
Tokudome, Shinkan
Suzuki, Koji
Hashimoto, Shuji
Wada, Yasuhiko
Kawamura, Takashi
Watanabe, Yoshiyuki
Ozasa, Kotaro
Miki, Tsuneharu
Date, Chigusa
Sakata, Kiyomi
Kurozawa, Yoichi
Yoshimura, Takesumi
Shibata, Akira
Okamoto, Naoyuki
Shio, Hideo
Author's alias: 川村, 孝
Keywords: Shift work
Cohort study
Hazard ratio
Biliary tract cancer
Issue Date: 21-Oct-2015
Publisher: BioMed Central Ltd.
Journal title: BMC Cancer
Volume: 15
Thesis number: 757
Abstract: Background: There is increasing evidence suggesting that shift work involving night work may increase cancer risk. Methods: We examined the association between working rotating shifts and the risk of death from biliary tract cancer among Japanese men who participated in the Japan Collaborative Cohort Study. Of the 46, 395 men recruited, 22, 224 men aged 40-65 at baseline (1988-1990) who reported working full-time or were self-employed were included in the present analysis. The study subjects were followed through December 31, 2009. Information regarding occupation and lifestyle factors was collected using a self-administered questionnaire. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for the risk of death from biliary tract cancer in relation to shift work. Results: During a mean 17-year follow-up, we observed 94 biliary tract cancer deaths, including 23 deaths from gallbladder cancer and 71 deaths from extrahepatic bile duct cancer. Overall, shift work was associated with a statistically non-significant increase in the risk of biliary tract cancer, with an HR of 1.50 (95 % CI: 0.81-2.77), among rotating shift workers. When the analysis was limited to extrahepatic bile duct cancer, a significant association appeared, with a multivariable-adjusted HR of 1.93 (95 % CI: 1.00-3.72) for rotating shift workers. Conclusion: Our data indicate that shift work may be associated with increased risk of death from extrahepatic bile duct cancer in this cohort of Japanese men. The association with gallbladder cancer remains unclear because of the small number of deaths.
Rights: © 2015 Lin et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
DOI(Published Version): 10.1186/s12885-015-1722-y
PubMed ID: 26490349
Appears in Collections:Journal Articles

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