このアイテムのアクセス数: 206
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s12970-015-0067-x.pdf | 911.59 kB | Adobe PDF | 見る/開く |
タイトル: | Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism |
著者: | Aoi, Wataru Ogaya, Yumi Takami, Maki Konishi, Toru Sauchi, Yusuke Park, Young Y. Wada, Sayori Sato, Kenji ![]() ![]() ![]() Higashi, Akane |
著者名の別形: | 佐藤, 健司 |
キーワード: | Glutathione Dkeletal muscle Lipid metabolism Running exercise PGC-1α |
発行日: | 6-Feb-2015 |
出版者: | BioMed Central Ltd. |
誌名: | Journal of the International Society of Sports Nutrition |
巻: | 12 |
論文番号: | 7 |
抄録: | Backgrounds: Glutathione is an endogenous redox couple in animal cells and plays important roles in antioxidant defense and detoxification, although it is unknown if oral glutathione supplementation affects exercise-induced physiological changes. The present study investigated the effect of glutathione intake on exercise-induced muscle metabolism and fatigue in mice and humans. Methods: ICR mice were divided into 4 groups: sedentary control, sedentary supplemented with glutathione (2.0%, 5μL/g body weight), exercise control, and exercise supplemented with glutathione. After 2weeks, the exercise groups ran on a treadmill at 25m/min for 30min. Immediately post-exercise, intermuscular pH was measured, and hind limb muscle and blood samples were collected to measure biochemical parameters. In a double-blind, cross-over study, 8 healthy men (35.9 ± 2.0 y) were administered either glutathione (1g/d) or placebo for 2weeks. Then, they exercised on a cycle ergometer at 40% maximal heart rate for 60min. Psychological state and blood biochemical parameters were examined after exercise. Results: In the mouse experiment, post-exercise plasma non-esterified fatty acids were significantly lower in the exercise supplemented with glutathione group (820 ± 44mEq/L) compared with the exercise control group (1152 ± 61mEq/L). Intermuscular pH decreased with exercise (7.17 ± 0.01); however, this reduction was prevented by glutathione supplementation (7.23 ± 0.02). The peroxisome proliferator-activated receptor-γ coactivator-1α protein and mitochondrial DNA levels were significantly higher in the sedentary supplemented with glutathione group compared with the sedentary control group (25% and 53% higher, respectively). In the human study, the elevation of blood lactate was suppressed by glutathione intake (placebo, 3.4 ± 1.1mM; glutathione, 2.9 ± 0.6mM). Fatigue-related psychological factors were significantly decreased in the glutathione trial compared with the placebo trial. Conclusions: These results suggest that glutathione supplementation improved lipid metabolism and acidification in skeletal muscles during exercise, leading to less muscle fatigue. |
著作権等: | © Aoi et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
URI: | http://hdl.handle.net/2433/213600 |
DOI(出版社版): | 10.1186/s12970-015-0067-x |
PubMed ID: | 25685110 |
出現コレクション: | 学術雑誌掲載論文等 |

このリポジトリに保管されているアイテムはすべて著作権により保護されています。