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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| fimmu.2015.00301.pdf | 464 kB | Adobe PDF | 見る/開く |
| タイトル: | CXCL12/SDF-1 and CXCR4 |
| 著者: | Nagasawa, Takashi |
| 著者名の別形: | 長澤, 丘司 |
| キーワード: | CXCL12 CXCR4 bone marrow niche stem cells hematopoietic stem cells B cell Foxc1 |
| 発行日: | 12-Jun-2015 |
| 出版者: | Frontiers |
| 誌名: | Frontiers in Immunology |
| 巻: | 6 |
| 論文番号: | 301 |
| 抄録: | Chemokines are a large family of structurally related chemoattractive cytokines, which have four conserved cysteines forming two disulfide bonds, and act through seven-transmembrane-spanning receptors coupled to heterotrimeric GTP-binding proteins (G-protein-coupled receptors). Chemokines were thought to be signaling molecules that attract leukocytes to sites of inflammation; however, CXC chemokine ligand (CXCL)12 [also known as stromal cell-derived factor (SDF)-1α and pre-B-cell-growth-stimulating factor (PBSF)] is the first member that was shown to be critical for developmental processes, including hematopoiesis (1), cardiogenesis (1–3), vascular formation (2), and neurogenesis (3), as well as the maintenance of tissue stem cells (4). |
| 著作権等: | © 2015 Nagasawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| URI: | http://hdl.handle.net/2433/214284 |
| DOI(出版社版): | 10.3389/fimmu.2015.00301 |
| PubMed ID: | 26124757 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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