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Title: Guanine-rich sequences are a dominant feature of exosomal microRNAs across the mammalian species and cell types
Authors: Momose, Fumiyasu
Seo, Naohiro
Akahori, Yasushi
Sawada, Shin Ichi
Harada, Naozumi
Ogura, Toru
Akiyoshi, Kazunari
Shiku, Hiroshi
Author's alias: 澤田, 晋一
秋吉, 一成
Issue Date: 21-Apr-2016
Publisher: Public Library of Science
Journal title: PLOS ONE
Volume: 11
Issue: 4
Thesis number: e0154134
Abstract: Exosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells. Exosomal miRNAs act as an effector during communication with appropriate recipient cells, this can aid in the utilization of the exosomes in a drug delivery system for various disorders including malignancies. Differences in the miRNA distribution pattern between exosomes and donor cells indicate the active translocation of miRNAs into the exosome cargos in a miRNA sequencedependent manner, although the molecular mechanism is little known. In this study, we statistically analyzed the miRNA microarray data and revealed that the guanine (G)-rich sequence is a dominant feature of exosome-dominant miRNAs, across the mammalian species-specificity and the cell types. Our results provide important information regarding the potential use of exosome cargos to develop miRNA-based drugs for the treatment of human diseases.
Rights: © 2016 Momose et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/214497
DOI(Published Version): 10.1371/journal.pone.0154134
Appears in Collections:Journal Articles

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