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Title: Voxel based analysis of surgical revascularization for moyamoya disease: Pre- and postoperative SPECT studies
Authors: Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Takagi, Yasushi
Funaki, Takeshi  kyouindb  KAKEN_id
Takahashi, Jun C.
Miyamoto, Susumu
Togashi, Kaori
Author's alias: 伏見, 育崇
髙木, 康志
舟木, 健史
宮本, 享
Issue Date: 11-Feb-2016
Publisher: Public Library of Science
Journal title: PLOS ONE
Volume: 11
Issue: 2
Thesis number: e0148925
Abstract: Moyamoya disease (MMD) is a chronic, progressive, cerebrovascular occlusive disease that causes abnormal enlargement of collateral pathways (moyamoya vessels) in the region of the basal ganglia and thalamus. Cerebral revascularization procedures remain the preferred treatment for patients with MMD, improving the compromised cerebral blood flow (CBF). However, voxel based analysis (VBA) of revascularization surgery for MMD based on data from pre- and postoperative data has not been established. The latest algorithm called as Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) has been introduced for VBA as the function of statistical parametric mapping (SPM8), and improved registration has been achieved by SPM8 with DARTEL. In this study, VBA was conducted to evaluate pre- and postoperative single photon emission computed tomography (SPECT) images for MMD by SPM8 with DARTEL algorithm, and the results were compared with those from SPM8 without DARTEL (a conventional method). Thirtytwo patients with MMD who underwent superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery as the first surgery were included and all patients underwent pre- and postoperative 3D T1-weighted imaging and SPECT. Pre- and postoperative SPECT images were registered to 3D T1-weighted images, then VBA was conducted. Postoperative SPECT showed more statistically increased CBF areas in the bypassed side cerebral hemisphere by using SPM8 with DARTEL (58, 989 voxels; P<0.001), and increased ratio of CBF after operation was less than 15%. Meanwhile, postoperative SPECT showed less CBF increased areas by SPM8 without DARTEL. In conclusion, VBA was conducted for patients with MMD, and SPM8 with DARTEL revealed that postoperative SPECT showed statistically significant CBF increases over a relatively large area and with at most 15% increase ratio.
Rights: Copyright © 2016 Fushimi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0148925
PubMed ID: 26867219
Appears in Collections:Journal Articles

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